Cancer risk in childhood-onset systemic lupus

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dc.contributor.authorBernatsky, Sasha
dc.contributor.authorClarke, Ann E
dc.contributor.authorLabrecque, Jeremy
dc.contributor.authorvon Scheven, Emily
dc.contributor.authorSchanberg, Laura E
dc.contributor.authorSilverman, Earl D
dc.contributor.authorBrunner, Hermine I
dc.contributor.authorHaines, Kathleen A
dc.contributor.authorCron, Randy Q
dc.contributor.authorO’Neil, Kathleen M
dc.contributor.authorOen, Kiem
dc.contributor.authorRosenberg, Alan M
dc.contributor.authorDuffy, Ciarán M
dc.contributor.authorJoseph, Lawrence
dc.contributor.authorLee, Jennifer L
dc.contributor.authorKale, Mruganka
dc.contributor.authorTurnbull, Elizabeth M
dc.contributor.authorRamsey-Goldman, Rosalind
dc.date.accessioned2013-12-05T16:37:08Z
dc.date.available2013-12-05T16:37:08Z
dc.date.issued2013-11-22
dc.date.updated2013-12-05T16:37:08Z
dc.description.abstractAbstract Introduction The aim of this study was to assess cancer incidence in childhood-onset systemic lupus erythematosus (SLE). Methods We ascertained cancers within SLE registries at 10 pediatric centers. Subjects were linked to cancer registries for the observational interval, spanning 1974 to 2009. The ratio of observed to expected cancers represents the standardized incidence ratio (SIR) or relative cancer risk in childhood-onset SLE, versus the general population. Results There were 1020 patients aged <18 at cohort entry. Most (82%) were female and Caucasian; mean age at cohort entry was 12.6 years (standard deviation (SD) = 3.6). Subjects were observed for a total of 7,986 (average 7.8) patient-years. Within this interval, only three invasive cancers were expected. However, 14 invasive cancers occurred with an SIR of 4.7, 95% confidence interval (CI) 2.6 to 7.8. Three hematologic cancers were found (two non-Hodgkin’s lymphoma, one leukemia), for an SIR of 5.2 (95% CI 1.1 to 15.2). The SIRs stratified by age group and sex, were similar across these strata. There was a trend for highest cancer occurrence 10 to 19 years after SLE diagnosis. Conclusions These results suggest an increased cancer risk in pediatric onset SLE versus the general population. In absolute terms, this represents relatively few events. Of note, risk may be highest only after patients have transferred to adult care.
dc.description.versionPeer Reviewed
dc.identifier.citationArthritis Research & Therapy. 2013 Nov 22;15(6):R198
dc.identifier.doihttp://dx.doi.org/10.1186/ar4388
dc.identifier.urihttp://hdl.handle.net/1993/22294
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderSasha Bernatsky et al.; licensee BioMed Central Ltd.
dc.titleCancer risk in childhood-onset systemic lupus
dc.typeJournal Article
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