Antenatal exposure to antibiotics and the risk of chronic diseases in childhood: a population-based study

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dc.contributor.authorChandrakumar, Abin
dc.contributor.examiningcommitteeHatch, Grant (Pharmacology and Therapeutics) Seshia, Molly (Pediatrics and Child Health)en_US
dc.contributor.supervisor't Jong, Geert (Pharmacology and Therapeutics)en_US
dc.date.accessioned2019-01-07T18:19:19Z
dc.date.available2019-01-07T18:19:19Z
dc.date.issued2018-12en_US
dc.date.submitted2018-12-19T22:19:26Zen
dc.date.submitted2019-01-07T18:04:38Zen
dc.degree.disciplinePharmacology and Therapeuticsen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractThe maternal microbiome plays an important role in shaping the microorganism development in the infant’s gut. The neonatal immune system development is driven by the gut microbiota and dysbiosis can precipitate chronic disease development during childhood. The aim of this study was to estimate the association of antenatal antibiotics and development of childhood chronic diseases study, in the 1996-2012 Manitoban birth cohort. Cox regression analyses were employed to determine these associations, and results are reported reporting them as adjusted hazard ratios (aHR) and confidence intervals (CI). Antenatal antibiotic exposure was significantly associated with an increased risk of severe allergy (aHR: 1.08; CI: 1.01-1.15), celiac disease (aHR: 1.59, CI: 1.46-1.71) and cholelithiasis (aHR: 1.46, CI: 1.21-1.77). Associations remained significant after being classified by antibiotic type. There was also a dose-response with increasing risk of celiac disease and cholelithiasis following multiple antenatal antibiotic exposures. The timing of antenatal exposure, however, did not modify the associations, and the associations for childhood celiac disease and cholelithiasis were similar for maternal antibiotic use during the nine months before and after pregnancy. Although our results revealed a potential risk of childhood severe allergy, celiac disease and cholelithiasis among offspring of mothers exposed to antenatal antibiotics, a similar risk associated with maternal antibiotic exposure during the 9-months before pregnancy and 9-months after pregnancy periods for the three diseases contradicts an exclusive association.en_US
dc.description.noteFebruary 2019en_US
dc.identifier.urihttp://hdl.handle.net/1993/33631
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectAntibioticsen_US
dc.subjectPediatricen_US
dc.subjectChronic diseasesen_US
dc.subjectManitobaen_US
dc.subjectDatabase studyen_US
dc.subjectPerinatalen_US
dc.titleAntenatal exposure to antibiotics and the risk of chronic diseases in childhood: a population-based studyen_US
dc.typemaster thesisen_US
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