Geo-epidemiology of autoantibodies in rheumatoid arthritis: comparison between four ethnically diverse populations

dc.contributor.authorde Moel, Emma C.
dc.contributor.authorTrouw, Leendert A.
dc.contributor.authorTerao, Chikashi
dc.contributor.authorGovind, Nimmisha
dc.contributor.authorTikly, Mohammed
dc.contributor.authorEl-Gabalawy, Hani
dc.contributor.authorSmolik, Irene
dc.contributor.authorBang, Holger
dc.contributor.authorHuizinga, Tom W.
dc.contributor.authorToes, Rene E.M.
dc.contributor.authorvan der Woude, Diane
dc.date.accessioned2023-05-01T15:53:05Z
dc.date.available2023-05-01T15:53:05Z
dc.date.issued2023-03-08
dc.date.updated2023-04-04T17:42:29Z
dc.description.abstractAbstract Background Rheumatoid arthritis (RA) occurs across the globe in different ethnic populations. Most RA patients harbor anti-modified protein antibodies (AMPA); however, it is unclear whether differences exist in autoantibody responses at different geographic locations and between different ethnic groups, which could provide new clues regarding factors underlying autoantibody development. We therefore investigated AMPA prevalence and association with HLA DRB1 alleles and smoking in four ethnically diverse populations on four different continents. Methods Anti-carbamylated (anti-CarP), anti-malondialdehyde acetaldehyde (anti-MAA), and anti-acetylated protein antibodies (anti-AcVim) IgG were determined in anti-citrullinated protein antibody-positive Dutch (NL, n = 103), Japanese (JP, n = 174), First Nations Peoples in Canada (FN, n = 100), and black South African (SA, n = 67) RA patients. Ethnicity-matched local healthy controls were used to calculate cut-offs. Risk factors associated with AMPA seropositivity in each cohort were identified using logistic regression. Results Median AMPA levels were higher in First Nations Peoples in Canada and especially South African patients, as reflected by percentage seropositivity: NL, JP, FN, and SA: anti-CarP: 47%, 43%, 58%, and 76% (p < 0.001); anti-MAA: 29%, 22%, 29%, and 53% (p < 0.001); and anti-AcVim: 20%, 17%, 38%, and 28% (p < 0.001). Total IgG levels also differed markedly, and when autoantibody levels were normalized to total IgG, differences between cohorts became less pronounced. Although there were some associations with AMPA and HLA risk alleles and smoking, none was consistent across all four cohorts. Conclusions AMPA against various post-translational modifications could consistently be detected on different continents across ethnically diverse RA populations. Differences in AMPA levels corresponded to differences in total serum IgG levels. This suggests that, despite differences in risk factors, a common pathway may be involved in AMPA development across geographic locations and ethnicities.en_US
dc.identifier.citationArthritis Research & Therapy. 2023 Mar 08;25(1):37
dc.identifier.citationArthritis Research & Therapy. 2023 Mar 08;25(1):37
dc.identifier.urihttps://doi.org/10.1186/s13075-023-03009-7
dc.identifier.urihttp://hdl.handle.net/1993/37320
dc.language.isoengen_US
dc.language.rfc3066en
dc.publisherBioMed Central (BMC)en_US
dc.rightsopen accessen_US
dc.rights.holderThe Author(s)
dc.titleGeo-epidemiology of autoantibodies in rheumatoid arthritis: comparison between four ethnically diverse populationsen_US
dc.typejournal articleen_US
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Internal Medicineen_US
oaire.citation.issue1en_US
oaire.citation.startPage37en_US
oaire.citation.titleArthritis Research & Therapyen_US
oaire.citation.volume25en_US
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