Background: Existing literature on raising disabled children in Ghana indicates that caregivers are faced with numerous challenges, some of them have adopted strategies in dealing with challenges that come with their work. Purpose: This thesis seeks to investigate the socio-cultural barriers faced by caregivers of children with disabilities in the Bosomtwe District of Ghana. Method: This study utilized a qualitative descriptive approach to explore the socio-cultural barriers faced by caregivers of disabled children in the Bosomtwe District of Ghana. Purposive sampling was used to select a sample of 7 caregivers, each with a child from one of the three main impairment groups (visual, hearing, and physical). Interviews were conducted via virtual platforms such as Zoom or via telephone with the use of an interview guide. Data analysis was performed using NVivo Qualitative Data Analysis software. Findings: This study found caregivers of disabled children in Ghana face barriers including lack of inclusive education, financial constraints, limited healthcare, transportation issues, and negative attitudes. To cope, caregivers networked, educated themselves, advocated for children, sought non-governmental organization (NGO) support, and remained resilient. Findings provide insights into caregiver challenges and resilience, informing supports needed. Conclusions: This study illuminated the challenges Ghanaian caregivers face through first-hand accounts. Findings underscore the need for greater formal and community supports. Further research on caregiver perspectives is critical to advocacy efforts.