dc.contributor.author	Guedou, Fernand A
dc.contributor.author	Van Damme, Lut
dc.contributor.author	Deese, Jennifer
dc.contributor.author	Crucitti, Tania
dc.contributor.author	Becker, Marissa
dc.contributor.author	Mirembe, Florence
dc.contributor.author	Solomon, Suniti
dc.contributor.author	Alary, Michel
dc.date.accessioned	2013-05-16T15:15:07Z
dc.date.available	2013-05-16T15:15:07Z
dc.date.issued	2013-05-08
dc.date.updated	2013-05-16T15:15:07Z
dc.description.abstract	Abstract Background Data on risk factors of recurrent bacterial vaginosis (RBV) are still scarce. We used data from female sex workers (FSW) participating in a randomized controlled microbicide trial to examine predictors of BV recurrence. Methods Trial’s participants with at least an episode of BV which was treated and/or followed by a negative BV result and at least one subsequent visit offering BV testing were included in the analysis. Behavioural and medical data were collected monthly while laboratory testing for STI and genital tract infections were performed quarterly. The Andersen-Gill proportional hazards model was used to determine predictors of BV recurrence both in bivariate and multivariate analyses. Results 440 women were included and the incidence rate for RBV was 20.8 recurrences/100 person-months (95% confidence interval (CI) =18.1–23.4). In the multivariate analysis controlling for the study site, recent vaginal cleansing as reported at baseline with adjusted hazard-ratio (aHR)=1.30, 95% CI = 1.02-1.64 increased the risk of BV recurrence, whereas consistent condom use (CCU) with the primary partner (aHR=0.68, 95% CI=0.49-0.93) and vaginal candidiasis (aHR=0.70, 95% CI=0.53-0.93), both treated as time-dependent variables, were associated with decreased risk of RBV. Conclusion This study confirms the importance of counselling high-risk women with RBV about the adverse effects of vaginal cleansing and the protective effects of condom use with all types of partners for the prevention of sexually transmitted infections, including BV. More prospective studies on risk factors of BV recurrence are warranted. Trial registration Trial registration: NCT00153777
dc.description.version	Peer Reviewed
dc.identifier.citation	BMC Infectious Diseases. 2013 May 08;13(1):208
dc.identifier.doi	http://dx.doi.org/10.1186/1471-2334-13-208
dc.identifier.uri	http://hdl.handle.net/1993/20395
dc.language.rfc3066	en
dc.rights	open access	en_US
dc.rights.holder	Fernand A Guédou et al.; licensee BioMed Central Ltd.
dc.title	Behavioural and medical predictors of bacterial vaginosis recurrence among female sex workers: longitudinal analysis from a randomized controlled trial
dc.type	Journal Article

Behavioural and medical predictors of bacterial vaginosis recurrence among female sex workers: longitudinal analysis from a randomized controlled trial

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