Hypothetical endogenous SIV-like antigens in Mauritian cynomolgus macaques

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dc.contributor.authorLi, Hongzhao
dc.contributor.authorLi, Lin
dc.contributor.authorLiu, Lewis
dc.contributor.authorOmange, Were
dc.contributor.authorToledo, Nikki
dc.contributor.authorKashem, Mohammad
dc.contributor.authorHai, Yan
dc.contributor.authorLiang, Binhua
dc.contributor.authorPlummer, Francis
dc.contributor.authorLuo, Ma
dc.date.accessioned2021-08-12T16:51:46Z
dc.date.available2021-08-12T16:51:46Z
dc.date.issued2018-02-28
dc.date.submitted2021-08-12T02:27:43Zen_US
dc.description.abstractSimian immunodeficiency virus (SIV) infection of Mauritian cynomolgus macaques (MCMs) is an increasingly important nonhuman primate model for HIV vaccine research. We previously reported that in MCMs anti-SIV antibodies can be naturally developed without exogenous infection or vaccination, and that a vaccine targeting SIV protease cleavage sites (PCS) can cross-induce antibodies to non-PCS SIV antigens. We speculate that this is potentially caused by the existence of endogenous SIV-like antigens. External stimuli (such as environmental factors and vaccination) may induce expression of endogenous SIV-like antigens to elicit these antibodies. Database and mass spectrometry analyses were conducted to search for such antigens. We identified endogenous SIV-like DNA sequences in cynomolgus macaque genome and non-PCS peptide homologous to SIV Env protein in PBMCs of a PCS-vaccinated monkey. Our preliminary insights suggest that endogenous SIV-like antigens may be one of the possible reasons for the natural and cross-inducible SIV antibodies in MCMs.en_US
dc.identifier.citationLi H, Li L, Liu LR, Omange RW, Toledo N, Kashem MA, Hai Y, Liang B, Plummer FA, Luo M. Hypothetical endogenous SIV-like antigens in Mauritian cynomolgus macaques. Bioinformation. 2018 Feb 28;14(2):48-52. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5879946/en_US
dc.identifier.doi10.6026/97320630014048
dc.identifier.otherPMCID: PMC5879946
dc.identifier.urihttp://hdl.handle.net/1993/35799
dc.language.isoengen_US
dc.publisherBioinformationen_US
dc.rightsopen accessen_US
dc.subjectSIVen_US
dc.subjectMauritian cynomolgus macaquesen_US
dc.subjectHIVen_US
dc.subjectvaccineen_US
dc.subjectprotease cleavage sites (PCS)en_US
dc.subjectnon-PCSen_US
dc.subjectdatabaseen_US
dc.titleHypothetical endogenous SIV-like antigens in Mauritian cynomolgus macaquesen_US
dc.typeArticleen_US
local.author.affiliationRady Faculty of Health Sciencesen_US
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