Mental comorbidity and multiple sclerosis: validating administrative data to support population-based surveillance

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dc.contributor.authorMarrie, Ruth Ann
dc.contributor.authorFisk, John D
dc.contributor.authorYu, Bo Nancy
dc.contributor.authorLeung, Stella
dc.contributor.authorElliott, Lawrence
dc.contributor.authorCaetano, Patricia
dc.contributor.authorWarren, Sharon
dc.contributor.authorEvans, Charity
dc.contributor.authorWolfson, Christina
dc.contributor.authorSvenson, Lawrence W
dc.contributor.authorTremlett, Helen
dc.contributor.authorBlanchard, James F
dc.contributor.authorPatten, Scott B
dc.contributor.authorfor the CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis
dc.date.accessioned2013-03-08T12:08:56Z
dc.date.available2013-03-08T12:08:56Z
dc.date.issued2013-02-06
dc.date.updated2013-03-08T12:08:57Z
dc.description.abstractAbstract Background While mental comorbidity is considered common in multiple sclerosis (MS), its impact is poorly defined; methods are needed to support studies of mental comorbidity. We validated and applied administrative case definitions for any mental comorbidities in MS. Methods Using administrative health data we identified persons with MS and a matched general population cohort. Administrative case definitions for any mental comorbidity, any mood disorder, depression, anxiety, bipolar disorder and schizophrenia were developed and validated against medical records using a a kappa statistic (k). Using these definitions we estimated the prevalence of these comorbidities in the study populations. Results Compared to medical records, administrative definitions showed moderate agreement for any mental comorbidity, mood disorders and depression (all k ≥ 0.49), fair agreement for anxiety (k = 0.23) and bipolar disorder (k = 0.30), and near perfect agreement for schizophrenia (k = 1.0). The age-standardized prevalence of all mental comorbidities was higher in the MS than in the general populations: depression (31.7% vs. 20.5%), anxiety (35.6% vs. 29.6%), and bipolar disorder (5.83% vs. 3.45%), except for schizophrenia (0.93% vs. 0.93%). Conclusions Administrative data are a valid means of surveillance of mental comorbidity in MS. The prevalence of mental comorbidities, except schizophrenia, is increased in MS compared to the general population.
dc.description.versionPeer Reviewed
dc.identifier.citationBMC Neurology. 2013 Feb 06;13(1):16
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2377-13-16
dc.identifier.urihttp://hdl.handle.net/1993/17594
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderRuth Ann Marrie et al.; licensee BioMed Central Ltd.
dc.titleMental comorbidity and multiple sclerosis: validating administrative data to support population-based surveillance
dc.typeJournal Article
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