Differentially private genome data dissemination through top-down specialization

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dc.contributor.authorWang, Shuang
dc.contributor.authorMohammed, Noman
dc.contributor.authorChen, Rui
dc.date.accessioned2014-12-12T21:23:42Z
dc.date.available2014-12-12T21:23:42Z
dc.date.issued2014-12-08
dc.date.updated2014-12-11T20:11:58Z
dc.description.abstractAbstract Advanced sequencing techniques make large genome data available at an unprecedented speed and reduced cost. Genome data sharing has the potential to facilitate significant medical breakthroughs. However, privacy concerns have impeded efficient genome data sharing. In this paper, we present a novel approach for disseminating genomic data while satisfying differential privacy. The proposed algorithm splits raw genome sequences into blocks, subdivides the blocks in a top-down fashion, and finally adds noise to counts to preserve privacy. The experimental results suggest that the proposed algorithm can retain certain data utility in terms of a high sensitivity.
dc.description.versionPeer Reviewed
dc.identifier.citationBMC Medical Informatics and Decision Making. 2014 Dec 08;14(Suppl 1):S2
dc.identifier.doihttp://dx.doi.org/10.1186/1472-6947-14-S1-S2
dc.identifier.urihttp://hdl.handle.net/1993/30109
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderShuang Wang et al.; licensee BioMed Central Ltd.
dc.titleDifferentially private genome data dissemination through top-down specialization
dc.typeJournal Article
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