Bacteria-activated macrophage membrane coated ROS-responsive nanoparticle for targeted delivery of antibiotics to infected wounds

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dc.contributor.authorLuo, Ying
dc.contributor.authorJia, Xiaoli
dc.contributor.authorWu, Xiaozhuo
dc.contributor.authorDiao, Ling
dc.contributor.authorZhao, Yawei
dc.contributor.authorLiu, Xing
dc.contributor.authorPeng, Yi
dc.contributor.authorZhong, Wen
dc.contributor.authorxing, malcolm
dc.contributor.authorLyu, Guozhong
dc.date.accessioned2025-01-24T17:47:33Z
dc.date.available2025-01-24T17:47:33Z
dc.date.issued2024-12-19
dc.date.updated2025-01-01T04:24:47Z
dc.description.abstractAbstract Bacterial infections and antibiotic resistance represent significant global public health challenges, necessitating the development of innovative antibacterial agents with targeted delivery capabilities. Our study utilized macrophages’ natural ability to recognize bacteria and the increased reactive oxygen species (ROS) at infection sites to develop a novel nanoparticle for targeted delivery and controlled release. We prepared bacteria-activated macrophage membranes triggered by Staphylococcus aureus (Sa-MMs), which showed significantly higher expression of Toll-like receptors (TLRs), compared to normal macrophage membranes (MMs). These Sa-MMs were then used to coat vancomycin-loaded amphiphilic nanoparticles with ROS responsiveness (Van-NPs), resulting in the novel targeted delivery system Sa-MM@Van-NPs. Studies both In vitro and in vivo demonstrated that biocompatible Sa-MM@Van-NPs efficiently targeted infected sites and released vancomycin to eliminate bacteria, facilitating faster wound healing. By combining targeted delivery to infected sites and ROS-responsive antibiotic release, this approach might represent a robust strategy for precise infection eradication and enhanced wound healing.
dc.identifier.citationJournal of Nanobiotechnology. 2024 Dec 19;22(1):781
dc.identifier.doi10.1186/s12951-024-03056-5
dc.identifier.urihttp://hdl.handle.net/1993/38843
dc.language.isoeng
dc.language.rfc3066en
dc.publisherBMC
dc.rights.holderThe Author(s)
dc.subjectBacteria-activation
dc.subjectMacrophage membrane
dc.subjectROS-responsive nanoparticle
dc.subjectTargeted delivery
dc.titleBacteria-activated macrophage membrane coated ROS-responsive nanoparticle for targeted delivery of antibiotics to infected wounds
dc.typeJournal Article
local.author.affiliationPrice Faculty of Engineering::Department of Mechanical Engineering
oaire.citation.issue781
oaire.citation.titleJournal of Nanobiotechnology
oaire.citation.volume22
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