The effect of statin use on the incidence of prostate cancer: a population-based nested case-control study
| dc.contributor.author | Dawe, David | |
| dc.contributor.examiningcommittee | Czaykowski, Piotr (Community Health Sciences) Jassal, Davinder (Internal Medicine) | en_US |
| dc.contributor.supervisor | Mahmud, Salaheddin (Community Health Sciences) | en_US |
| dc.date.accessioned | 2017-08-25T20:50:56Z | |
| dc.date.available | 2017-08-25T20:50:56Z | |
| dc.date.issued | 2017 | |
| dc.degree.discipline | Community Health Sciences | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Literature review revealed a compelling pre-clinical rationale for statins as chemopreventive agents for prostate cancer (PC). However, epidemiological literature results vary widely. We completed a nested case-control study investigating the impact of statin use on PC diagnosis using data from men aged >=40 years in Saskatchewan between 1990-2010. Drug exposure histories were derived from a population-based prescription drug database. We used conditional logistic regression to model use of statins. 12,745 cases of PC were risk-set matched on age and geographic location to 50,979 controls. 2064 (16.2%) cases and 7956 (15.6%) controls were dispensed one or more statin prescriptions. In multivariable models, ever prescription of statins was not associated with PC diagnosis (OR 0.97; 95% CI 0.90-1.05). Diagnosis of clinically significant PC decreased with statin use (OR 0.84, 95% CI 0.73-0.97). Statin use is not associated with PC risk, but is associated with a decreased risk of clinically significant PC. | en_US |
| dc.description.note | October 2017 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/32380 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Pharmacoepidemiology | en_US |
| dc.subject | Chemoprevention | en_US |
| dc.subject | Prostate cancer | en_US |
| dc.subject | Statins | en_US |
| dc.title | The effect of statin use on the incidence of prostate cancer: a population-based nested case-control study | en_US |
| dc.type | master thesis | en_US |