A microfluidic-based microwave interferometric inductance sensor capable of detecting single micron-size superparamagnetic particles in flow

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dc.contributor.authorRzeszowski, Szymon
dc.contributor.examiningcommitteeOliver, Derek (Electrical & Computer Engineering) Hu, Can-Ming (Physics and Astronomy)en_US
dc.contributor.supervisorBridges, Greg (Electrical & Computer Engineering)en_US
dc.date.accessioned2012-09-19T15:06:20Z
dc.date.available2012-09-19T15:06:20Z
dc.date.issued2012-09-19
dc.degree.disciplineElectrical and Computer Engineeringen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractA microfluidic-based inductance sensor operating at 1.5 GHz is presented that can detect single 4.5 μm superparamagnetic particles flowing in a microfluidic channel. The particles are detected as they pass over a micron-sized planar gold loop electrode, with a maximum signal-to-noise ratio of 26.3 dB for an 80 μm/s flow rate; the magnetic beads are simultaneously observed with microscope images. The sensor consists of a coupled-line resonator and microwave interferometric system coupled to the loop electrode that is integrated within a polydimethylsiloxane-on-glass microfluidic chip assembly. A time-averaged inductance change caused by a single particle is related to the real part of its magnetic Clausius-Mossotti factor. The effective real part of the magnetic permeability for a particular particle is estimated to be 1.13 at 1.5 GHz. The sensor detects magnetic particles in flow and does not require an external biasing magnetic field, which distinguishes it from other magnetic microparticle sensors.en_US
dc.description.noteOctober 2012en_US
dc.identifier.urihttp://hdl.handle.net/1993/8877
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectInductanceen_US
dc.subjectSensoren_US
dc.subjectMicrofluidicsen_US
dc.subjectSuperparamagneticen_US
dc.subjectMicrowaveen_US
dc.titleA microfluidic-based microwave interferometric inductance sensor capable of detecting single micron-size superparamagnetic particles in flowen_US
dc.typemaster thesisen_US
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