Biomarkers of perinatal hypoxia in a rat model
Loading...
Files
Date
2014-08-14
Authors
Tian, Na
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Hypoxia can result in brain injury. Hypoxic brain injury can also result in excess stress hormones and activated immune responses. In this study, we examined multiple spontaneous motor behaviors, concentrations of stress hormones, and gene expression of immune responses in rats after perinatal hypoxia. Hypoxic animals exhibited impaired spontaneous motor behaviors in several tests. Perinatal hypoxia also caused increased levels of stress hormones and altered expression of genes associated with adaptive and innate immunity at different time points after hypoxia exposure. Findings demonstrate stress hormones and immune responses are available to play an important role in perinatal brain injury and can impact delayed behavioral development.
Description
Keywords
perinatal hypoxia, preterm birth, immune responses, glucocorticoids, behavioral development