Metal-catalyzed cross-coupling reactions with dithiolanes and dithianes
| dc.contributor.author | McFarlane, Michael Thomas | |
| dc.contributor.examiningcommittee | Schweizer, Frank (Chemistry) Sorensen, John (Chemistry) Liu, Song (Textile Sciences) | en_US |
| dc.contributor.supervisor | Hultin, Philip G. (Chemistry) | en_US |
| dc.date.accessioned | 2012-12-19T18:00:32Z | |
| dc.date.available | 2012-12-19T18:00:32Z | |
| dc.date.issued | 2012-12-19 | |
| dc.degree.discipline | Chemistry | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Creating new carbon-carbon bonds is one of the most important and challenging reactions in organic synthesis. Metal-catalyzed cross-coupling reactions have emerged as one of the preferred methods of producing new carbon-carbon bonds, and this work led to the 2010 Nobel Prize in Chemistry. This thesis was aimed at expanding the current research in the area of metal-catalyzed cross-coupling reactions to include new applications with dithiolane and dithiane protecting groups. 1,3-Dithiolane and 1,3-dithiane derivatives are particularly interesting molecules in that they can be deprotonated by a strong base to form anions, which can then be used for carbon-carbon bond synthesis. This thesis describes the investigation into the use of dithiolanes and dithianes in metal-catalyzed cross-coupling reactions, as well as some of the challenges faced in performing this sulfur-based chemistry. | en_US |
| dc.description.note | February 2013 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/13706 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | cross-coupling | en_US |
| dc.subject | thioacetal | en_US |
| dc.subject | organohalide | en_US |
| dc.subject | Umpolung | en_US |
| dc.title | Metal-catalyzed cross-coupling reactions with dithiolanes and dithianes | en_US |
| dc.type | master thesis | en_US |