Epidemiological and Economic Burden of Pneumococcal Disease in Canadian Children

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Petit, Geneviève
De Wals, Philippe
Law, Barbara
Tam, Theresa
Erickson, Lonny James
Guay, Maryse
Framarin, Alicia
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BACKGROUND: With the arrival of a new conjugate pneumococcal vaccine, it is important to estimate the burden of pneumococcal diseases in Canadian children. The epidemiological data and the economic cost of these diseases are crucial elements in evaluating the relevance of a vaccination program.METHODS: Using provincial databases, ad hoc surveys and published data, age-specific incidence rates of pneumococcal infections were estimated in a cohort of 340,000 children between six months and nine years of age. The costs of these diseases to the health system and to families were also evaluated using data from Quebec and Manitoba.RESULTS: Cumulative risks were one in 5000 for pneumococcal meningitis, one in 500 for bacteremia and one in 20 for pneumonia, leading to 16 deaths in the cohort. About 262,000 otitis media episodes and 32,000 cases of myringotomy with ventilation tube insertion were attributable to Streptococcus pneumoniae. Societal costs were estimated at $125 million, of which 32% was borne by the health system and 68% was borne by families. Invasive infections represented only 2% of total costs, while 84% were generated by otitis media.CONCLUSION: Pneumococcal infections represent a significant burden for Canadian children and society that could be significantly reduced through immunization.
Geneviève Petit, Philippe De Wals, Barbara Law, et al., “Epidemiological and Economic Burden of Pneumococcal Disease in Canadian Children,” Canadian Journal of Infectious Diseases, vol. 14, no. 4, pp. 215-220, 2003. doi:10.1155/2003/781794