Analyses of Physcomitrella patens Ankyrin Repeat Proteins by Computational Approach

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dc.contributor.authorMahmood, Niaz
dc.contributor.authorTamanna, Nahid
dc.date.accessioned2016-08-03T17:31:25Z
dc.date.available2016-08-03T17:31:25Z
dc.date.issued2016-6-27
dc.date.updated2016-08-03T07:43:26Z
dc.description.abstractAnkyrin (ANK) repeat containing proteins are evolutionary conserved and have functions in crucial cellular processes like cell cycle regulation and signal transduction. In this study, through an entirely in silico approach using the first release of the moss genome annotation, we found that at least 54 ANK proteins are present in P. patens. Based on their differential domain composition, the identified ANK proteins were classified into nine subfamilies. Comparative analysis of the different subfamilies of ANK proteins revealed that P. patens contains almost all the known subgroups of ANK proteins found in the other angiosperm species except for the ones having the TPR domain. Phylogenetic analysis using full length protein sequences supported the subfamily classification where the members of the same subfamily almost always clustered together. Synonymous divergence (dS) and nonsynonymous divergence (dN) ratios showed positive selection for the ANK genes of P. patens which probably helped them to attain significant functional diversity during the course of evolution. Taken together, the data provided here can provide useful insights for future functional studies of the proteins from this superfamily as well as comparative studies of ANK proteins.
dc.description.versionPeer Reviewed
dc.identifier.citationNiaz Mahmood and Nahid Tamanna, “Analyses of Physcomitrella patens Ankyrin Repeat Proteins by Computational Approach,” Molecular Biology International, vol. 2016, Article ID 9156735, 8 pages, 2016. doi:10.1155/2016/9156735
dc.identifier.urihttp://dx.doi.org/10.1155/2016/9156735
dc.identifier.urihttp://hdl.handle.net/1993/31549
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2016 Niaz Mahmood and Nahid Tamanna. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleAnalyses of Physcomitrella patens Ankyrin Repeat Proteins by Computational Approach
dc.typeJournal Article
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