Play-the-winner rule and adaptive designs of clinical trials

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dc.contributor.authorWang, Xikui
dc.contributor.authorPullman, Daryl
dc.date.accessioned2014-08-14T07:07:18Z
dc.date.available2014-08-14T07:07:18Z
dc.date.issued2000-1-1
dc.date.updated2014-08-14T07:07:19Z
dc.description.abstractIn another paper, we have argued that the traditional randomized design of clinical trials is ethically infeasible in desperate medical situations and adaptive designs are morally required. We have also argued that in such situations, the appropriate designs must satisfy what we call the Principle of interchangeability. In this statistics paper, we show that the statistical model of bandit processes satisfies this principle of interchangeability. Moreover, we demonstrate that when such a model is used as an adaptive design, the total regret of successes lost is smaller when compared with simple randomization. We illustrate the results by the simple deterministic play-the-winner design.
dc.description.versionPeer Reviewed
dc.identifier.citationXikui Wang and Daryl Pullman, “Play-the-winner rule and adaptive designs of clinical trials,” International Journal of Mathematics and Mathematical Sciences, vol. 27, no. 4, pp. 229-236, 2001. doi:10.1155/S0161171201005750
dc.identifier.doihttp://dx.doi.org/10.1155/S0161171201005750
dc.identifier.urihttp://hdl.handle.net/1993/23790
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titlePlay-the-winner rule and adaptive designs of clinical trials
dc.typeJournal Article
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