Tissue correlates of hypoxic/ischemic MR imaging changes, differences between neonatal and young rats
| dc.contributor.author | Qiao, Min | en_US |
| dc.date.accessioned | 2007-05-18T12:17:47Z | |
| dc.date.available | 2007-05-18T12:17:47Z | |
| dc.date.issued | 1999-07-01T00:00:00Z | en_US |
| dc.degree.discipline | Physiology | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Diffusion-weighted (DW) and T2-weighted (TW) magnetic resonance (MR) imaging techniques have successfully detected ischemic changes in a variety of stroke models. Recently, it has been reported that there are age-dependent differences in the MR imaging changes observed during and after an episode of cerebral hypoxia/ischemia. The biophysical mechanisms for MR changes remain undefined. We hypothesized that the age-dependent MR changes in hypoxia/ischemia (occlusion of the right carotid artery plus exposure to 8% oxygen) were due to the developmental differences in hypoxia/ischemia-induced changes in brain water, cell volume control and/or cell death. Thus, we investigated the correlation between MR changes and alterations in brain water, Na -K+-ATPase activity, cytochrome oxidase activity and cell death at various times following the start of hypoxia/ischemia until 24 hours of reperfusion in neonatal (1 week old) and young (4 week old) rats. The results suggest that hypoxia/ischemia-induced T2 and DW changes reflect alterations in water content and Na+-K+-ATPase in neonatal brain, respectively. However, there is only a partial correspondence in young brain suggesting that there might be other factors contributing to the developmental differences in the visibility of hypoxic/ischemic MR changes. (Abstract shortened by UMI.) | en_US |
| dc.format.extent | 4054101 bytes | |
| dc.format.extent | 184 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | text/plain | |
| dc.identifier.uri | http://hdl.handle.net/1993/1705 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.title | Tissue correlates of hypoxic/ischemic MR imaging changes, differences between neonatal and young rats | en_US |
| dc.type | master thesis | en_US |