Treatment of T1b glottic SCC: laser vs. radiation- a Canadian multicenter study

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dc.contributor.authorTaylor, S Mark
dc.contributor.authorKerr, Paul
dc.contributor.authorFung, Kevin
dc.contributor.authorAneeshkumar, Mankavil K
dc.contributor.authorWilke, Derek
dc.contributor.authorJiang, Yida
dc.contributor.authorScott, John
dc.contributor.authorPhillips, Judith
dc.contributor.authorHart, Robert D
dc.contributor.authorTrites, Jonathan RB
dc.contributor.authorRigby, Matthew H
dc.date.accessioned2013-03-25T12:07:38Z
dc.date.available2013-03-25T12:07:38Z
dc.date.issued2013-03-19
dc.date.updated2013-03-25T12:07:38Z
dc.description.abstractAbstract Objective To assess the oncological and functional outcomes of T1b squamous cell carcinoma (SCC) of the glottic larynx treated with laser in comparison with radiation. Design A Canadian multicenter cohort study. Setting Three tertiary referral centers for head and neck cancer- Dalhousie University in Halifax, Nova Scotia, Western University in London, Ontario and the University of Manitoba, Winnipeg. Methods Patients with T1b glottic SCC who underwent transoral laser resection or radiation as the primary modality of treatment. Outcome measures Oncological outcomes were evaluated using local control, laryngeal preservation, disease free survival and disease specific survival. Voice outcomes were assessed using the Voice Handicap Index-10 (VHI-10). Results 63 patients met study criteria. 21 were treated with laser and 42 with radiation. Oncologic outcomes at 2 years for laser and radiation demonstrated local control of 95% and 85.9%; laryngeal preservation of 100% and 85.9%; disease free survival of 88.7% and 85.9% and overall survival of 94.1% and 94.8% respectively. VHI-10 data was available for 23/63 patients. During the last follow up visit VHI-10 ranged from 0 to 11 (median 6) in the laser group and 0 to 34 (median 7) in the radiation group. Conclusion T1b SCC of the glottis can be effectively treated with transoral laser microsurgery with oncological outcomes that are at least equivalent to radiation. For patients with VHI scores, voice quality was similar between the two groups. To our knowledge this is the first study directly comparing the oncologic and voice outcomes with laser and radiation for the treatment of glottic cancer involving the anterior commissure.
dc.description.versionPeer Reviewed
dc.identifier.citationJournal of Otolaryngology - Head and Neck Surgery. 2013 Mar 19;42(1):22
dc.identifier.doihttp://dx.doi.org/10.1186/1916-0216-42-22
dc.identifier.urihttp://hdl.handle.net/1993/17973
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderS Mark Taylor et al.; licensee BioMed Central Ltd.
dc.titleTreatment of T1b glottic SCC: laser vs. radiation- a Canadian multicenter study
dc.typeJournal Article
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