Factors Associated with Spontaneous Clearance of Hepatitis C Virus in Chinese Population

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dc.contributor.authorKong, Fei
dc.contributor.authorPan, Yu
dc.contributor.authorChi, Xiumei
dc.contributor.authorWang, Xiaomei
dc.contributor.authorChen, Linjiao
dc.contributor.authorLv, Juan
dc.contributor.authorSun, Haibo
dc.contributor.authorWu, Ruihong
dc.contributor.authorJin, Jinglan
dc.contributor.authorYu, Ge
dc.contributor.authorMa, Zhenhua
dc.contributor.authorWang, Yang
dc.contributor.authorHuang, Xinxing
dc.contributor.authorLi, Hua
dc.contributor.authorBai, Yang
dc.contributor.authorJia, Jing
dc.contributor.authorMinuk, Gerald Y.
dc.contributor.authorZhong, Jin
dc.contributor.authorSun, Bing
dc.contributor.authorJiang, Jing
dc.contributor.authorNiu, Junqi
dc.date.accessioned2014-08-14T06:36:08Z
dc.date.available2014-08-14T06:36:08Z
dc.date.issued2014-7-16
dc.date.updated2014-08-14T06:36:09Z
dc.description.abstractHepatitis C virus (HCV) infections spontaneously clear in approximately 15–45% of infected individuals. Factors which influence spontaneous HCV clearance remain to be identified. The purpose of the present study was to identify variables associated with spontaneous HCV clearance in a referred population of Chinese patients. The prevalence of host, viral, and environmental factors known to influence the outcome of HCV infections was compared in 92 HCV spontaneous clearance subjects and 318 HCV persistent infection subjects. Univariate and multivariate analyses were performed to identify those factors associated with spontaneous HCV clearance. In univariate analysis, female gender, a history of icteric hepatitis, serologic evidence of concurrent HBV infection, and rs12979860 CC genotype were positively associated with spontaneous HCV clearance, while alcohol consumption was negatively associated with clearance. In multivariate analysis, female gender, a history of icteric hepatitis, concurrent HBV infection, and rs12979860 CC genotype remained independent variables associated with spontaneous HCV clearance. Spontaneous HCV clearance is more likely to occur in females, subjects with a history of icteric hepatitis, HBV coinfections, and those with the rs12979860 CC genotype.
dc.description.versionPeer Reviewed
dc.identifier.citationFei Kong, Yu Pan, Xiumei Chi, et al., “Factors Associated with Spontaneous Clearance of Hepatitis C Virus in Chinese Population,” BioMed Research International, vol. 2014, Article ID 527030, 6 pages, 2014. doi:10.1155/2014/527030
dc.identifier.doihttp://dx.doi.org/10.1155/2014/527030
dc.identifier.urihttp://hdl.handle.net/1993/23753
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2014 Fei Kong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleFactors Associated with Spontaneous Clearance of Hepatitis C Virus in Chinese Population
dc.typeJournal Article
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