Eosinophils in human oral squamous carcinoma; role of prostaglandin D2

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dc.contributor.authorDavoine, Francis
dc.contributor.authorSim, Adrian
dc.contributor.authorTang, Charlie
dc.contributor.authorFisher, Sibina
dc.contributor.authorEthier, Caroline
dc.contributor.authorPuttagunta, Lakshmi
dc.contributor.authorWu, Yingqi
dc.contributor.authorMcGaw, W Tim
dc.contributor.authorYu, Donald
dc.contributor.authorCameron, Lisa
dc.contributor.authorAdamko, Darryl J
dc.contributor.authorMoqbel, Redwan
dc.date.accessioned2013-04-26T03:16:30Z
dc.date.available2013-04-26T03:16:30Z
dc.date.issued2013-01-31
dc.date.updated2013-04-26T03:16:31Z
dc.description.abstractAbstract Eosinophils are often predominant inflammatory leukocytes infiltrating oral squamous carcinoma (OSC) sites. Prostaglandins are secreted by oral carcinomas and may be involved in eosinophil infiltration. The objective of this study was to determine the factors contributing to eosinophil migration and potential anti-neoplastic effects on OSC. Eosinophil degranulation was evaluated by measuring release of eosinophil peroxidase (EPO). Eosinophil chemotaxis towards OSC cells was assessed using artificial basement membrane. Eosinophil infiltration was prominent within the tissue surrounding the OSC tumor mass. We observed growth inhibition of the OSC cell line, SCC-9, during co-culture with human eosinophils, in vitro, which correlated with EPO activity that possesses growth inhibitory activity. The PGD2 synthase inhibitor, HQL-79, abrogated migration towards SCC-9. Our data suggest that OSC-derived PGD2 may play an important role via CRTH2 (the PGD2 receptor on eosinophils) in eosinophil recruitment and subsequent anti-tumor activity through the action of eosinophil cationic proteins.
dc.description.versionPeer Reviewed
dc.identifier.citationJournal of Inflammation. 2013 Jan 31;10(1):4
dc.identifier.doihttp://dx.doi.org/10.1186/1476-9255-10-4
dc.identifier.urihttp://hdl.handle.net/1993/19684
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderFrancis Davoine et al.; licensee BioMed Central Ltd.
dc.titleEosinophils in human oral squamous carcinoma; role of prostaglandin D2
dc.typeJournal Article
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