The Emerging Use of In Vivo Optical Imaging in the Study of Neurodegenerative Diseases

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dc.contributor.authorPatterson, Aileen P.
dc.contributor.authorBooth, Stephanie A.
dc.contributor.authorSaba, Reuben
dc.date.accessioned2014-08-13T13:23:33Z
dc.date.available2014-08-13T13:23:33Z
dc.date.issued2014-7-23
dc.date.updated2014-08-13T13:23:34Z
dc.description.abstractThe detection and subsequent quantification of photons emitted from living tissues, using highly sensitive charged-couple device (CCD) cameras, have enabled investigators to noninvasively examine the intricate dynamics of molecular reactions in wide assortment of experimental animals under basal and pathophysiological conditions. Nevertheless, extrapolation of this in vivo optical imaging technology to the study of the mammalian brain and related neurodegenerative conditions is still in its infancy. In this review, we introduce the reader to the emerging use of in vivo optical imaging in the study of neurodegenerative diseases. We highlight the current instrumentation that is available and reporter molecules (fluorescent and bioluminescent) that are commonly used. Moreover, we examine how in vivo optical imaging using transgenic reporter mice has provided new insights into Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Prion disease, and neuronal damage arising from excitotoxicity and inflammation. Furthermore, we also touch upon studies that have utilized these technologies for the development of therapeutic strategies for neurodegenerative conditions that afflict humans.
dc.description.versionPeer Reviewed
dc.identifier.citationAileen P. Patterson, Stephanie A. Booth, and Reuben Saba, “The Emerging Use of In Vivo Optical Imaging in the Study of Neurodegenerative Diseases,” BioMed Research International, vol. 2014, Article ID 401306, 14 pages, 2014. doi:10.1155/2014/401306
dc.identifier.doihttp://dx.doi.org/10.1155/2014/401306
dc.identifier.urihttp://hdl.handle.net/1993/23748
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2014 Aileen P. Patterson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleThe Emerging Use of In Vivo Optical Imaging in the Study of Neurodegenerative Diseases
dc.typeJournal Article
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