The utility and application of non-invasive fluorescent imaging in murine models of allergic asthma
| dc.contributor.author | Lytwyn, Matthew | |
| dc.contributor.examiningcommittee | Kroeger, Edwin (Physiology and Pathophysiology) Soussi Gounni, Abdelilah (Immunology) Keijzer, Richard (Physiology and Pathophysiology) | en_US |
| dc.contributor.supervisor | Halayko, Andrew (Physiology and Pathophysiology) | en_US |
| dc.date.accessioned | 2018-01-12T15:56:16Z | |
| dc.date.available | 2018-01-12T15:56:16Z | |
| dc.date.issued | 2017 | |
| dc.degree.discipline | Physiology and Pathophysiology | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Allergic asthma is characterized by airway hyperresponsiveness and lung inflammation. To better understand disease pathophysiology, lung inflammation is monitored in animal models, and in this regard, non-invasive medical imaging is emerging for use in pre-clinical research. The primary aim of this project is to develop protocols using non-invasive fluorescent optical imaging to quantitate lung inflammation in response to allergic challenge in a murine model of asthma. Our studies show that in vivo optical imaging provides a meaningful, non-invasive measure of lung inflammation, including dye specific enzymatic activity such as for cathepsins, in murine models of allergic asthma. This approach is a new option for repeated measurements in individual animals for drug testing and development. | en_US |
| dc.description.note | February 2018 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/32823 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | asthma | en_US |
| dc.subject | respirology | en_US |
| dc.subject | medical imaging | en_US |
| dc.subject | spectral imaging | en_US |
| dc.title | The utility and application of non-invasive fluorescent imaging in murine models of allergic asthma | en_US |
| dc.type | master thesis | en_US |