Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study
| dc.contributor.author | Aviles-Solis, J. C | |
| dc.contributor.author | Jácome, C. | |
| dc.contributor.author | Davidsen, A. | |
| dc.contributor.author | Einarsen, R. | |
| dc.contributor.author | Vanbelle, S. | |
| dc.contributor.author | Pasterkamp, H. | |
| dc.contributor.author | Melbye, H. | |
| dc.date.accessioned | 2019-10-01T06:06:27Z | |
| dc.date.issued | 2019-09-11 | |
| dc.date.updated | 2019-10-01T06:06:28Z | |
| dc.description.abstract | Abstract Background Wheezes and crackles are well-known signs of lung diseases, but can also be heard in apparently healthy adults. However, their prevalence in a general population has been sparsely described. The objective of this study was to determine the prevalence of wheezes and crackles in a large general adult population and explore associations with self-reported disease, smoking status and lung function. Methods We recorded lung sounds in 4033 individuals 40 years or older and collected information on self-reported disease. Pulse oximetry and spirometry were carried out. We estimated age-standardized prevalence of wheezes and crackles and associations between wheezes and crackles and variables of interest were analyzed with univariable and multivariable logistic regressions. Results Twenty-eight percent of individuals had wheezes or crackles. The age-standardized prevalence of wheezes was 18.6% in women and 15.3% in men, and of crackles, 10.8 and 9.4%, respectively. Wheezes were mostly found during expiration and crackles during inspiration. Significant predictors of expiratory wheezes in multivariable analyses were age (10 years increase - OR 1.18, 95%CI 1.09–1.30), female gender (1.45, 1.2–1.8), self-reported asthma (1.36, 1.00–1.83), and current smoking (1.70, 1.28–2.23). The most important predictors of inspiratory crackles were age (1.76, 1.57–1.99), current smoking, (1.94, 1.40–2.69), mMRC ≥2 (1.79, 1.18–2.65), SpO2 (0.88, 0.81–0.96), and FEV1 Z-score (0.86, 0.77–0.95). Conclusions Nearly over a quarter of adults present adventitious lung sounds on auscultation. Age was the most important predictor of adventitious sounds, particularly crackles. The adventitious sounds were also associated with self-reported disease, current smoking and measures of lung function. The presence of findings in two or more auscultation sites was associated with a higher risk of decreased lung function than solitary findings. | |
| dc.identifier.citation | BMC Pulmonary Medicine. 2019 Sep 11;19(1):173 | |
| dc.identifier.uri | https://doi.org/10.1186/s12890-019-0928-1 | |
| dc.identifier.uri | http://hdl.handle.net/1993/34312 | |
| dc.language.rfc3066 | en | |
| dc.rights | open access | en_US |
| dc.rights.holder | The Author(s). | |
| dc.title | Prevalence and clinical associations of wheezes and crackles in the general population: the Tromsø study | |
| dc.type | Journal Article |