The effect of short-term endurance training on 5-HT1A, 5-HT2A and 5-HT2C receptor mRNA levels in rat lumbar motoneurons
| dc.contributor.author | Woodrow, Lindsey | |
| dc.contributor.examiningcommittee | Duhamel, Todd (Kinesiology and Recreation Management) Jordan, Larry (Physiology) | en |
| dc.contributor.supervisor | Gardiner, Phillip (Kinesiology and Recreation Management) | en |
| dc.date.accessioned | 2010-09-12T17:34:44Z | |
| dc.date.available | 2010-09-12T17:34:44Z | |
| dc.date.issued | 2010-09-12T17:34:44Z | |
| dc.degree.discipline | Kinesiology and Recreation Management | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Serotonin receptor subtypes 5-HT1A, 5-HT2A and 5-HT2C are expressed in motoneurons and modulate motoneuron excitability. Serotonergic neurons, which increase their discharge with motor activity, make numerous contacts with motoneurons; however, little is known about the adaptability of motoneuron serotonin receptor expression in response to exercise. The purpose of this study was to determine the effect of a 7-day treadmill exercise protocol on 5-HT1A, 5-HT2A and 5-HT2C receptor mRNA levels in rat lumbar motoneurons. Lumbar motoneurons of exercised and sedentary animals were collected via laser capture microdissection. RNA was isolated from these samples and real-time reverse transcription polymerase chain reactions were performed to determine differences in receptor mRNA levels between exercised and sedentary animals. It appears that 5-HT1A, 5-HT2A and 5-HT2C receptor mRNA levels are unaltered following 7 days of treadmill exercise; however, future research must be done to determine if an exercise effect exists when motoneurons are differentiated by type. | en |
| dc.description.note | October 2010 | en |
| dc.format.extent | 1174382 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/1993/4178 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | serotonin receptor | en |
| dc.subject | motoneuron | en |
| dc.subject | exercise | en |
| dc.subject | physical activity | en |
| dc.subject | exercise physiology | en |
| dc.subject | neuroscience | en |
| dc.subject | molecular biology | en |
| dc.title | The effect of short-term endurance training on 5-HT1A, 5-HT2A and 5-HT2C receptor mRNA levels in rat lumbar motoneurons | en |
| dc.type | master thesis | en_US |