Antioxidant activity of noni juice in heavy smokers

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dc.contributor.authorWang, Mian-Ying
dc.contributor.authorLutfiyya, M Nawal
dc.contributor.authorWeidenbacher-Hoper, Vicki
dc.contributor.authorAnderson, Gary
dc.contributor.authorSu, Chen X
dc.contributor.authorWest, Brett J
dc.date.accessioned2015-02-03T21:28:47Z
dc.date.available2015-02-03T21:28:47Z
dc.date.issued2009-10-06
dc.date.updated2015-02-03T16:03:28Z
dc.description.abstractAbstract Background Noni (Morinda citrifolia) juice has demonstrated antioxidant activity in vitro and in vivo. To evaluate this activity in humans, noni juice from Tahiti (TNJ) was evaluated in a 30 day, double-blind, and placebo controlled clinical trial with 285 current heavy smokers. Research participants were randomly assigned to three daily treatment groups: 118 mL placebo, 29.5 mL TNJ, and 118 mL TNJ. Plasma superoxide anion radicals (SAR) and lipid hydroperoxide (LOOH) levels were measured pre and post-intervention. Results After 30 days, mean SAR decreased from 0.26 ± 0.14 to 0.19 ± 0.10 μmol/mL in the 29.5 mL dose group (P < 0.01) and from 0.26 ± 0.22 to 0.18 ± 0.11 μmol/mL in the 118 mL dose group (P < 0.001). LOOH levels decreased from 0.53 ± 0.19 to 0.40 ± 0.10 μmol/mL in the 29.5 mL dose group (P < 0.001) and from 0.55 ± 0.21 to 0.40 ± 0.14 μmol/mL in the 118 mL dose group (P < 0.001). No significant reductions in SAR or LOOH levels were observed in the placebo group. Conclusion The results suggest an antioxidant activity from noni juice in humans exposed to tobacco smoke, thereby replicating the results found previous chemical and in vivo tests.
dc.description.versionPeer Reviewed
dc.identifier.citationChemistry Central Journal. 2009 Oct 06;3(1):13
dc.identifier.doihttp://dx.doi.org/10.1186/1752-153X-3-13
dc.identifier.urihttp://hdl.handle.net/1993/30251
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderMian-Ying Wang et al.; licensee BioMed Central Ltd.
dc.titleAntioxidant activity of noni juice in heavy smokers
dc.typeJournal Article
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