Evaluation of the lipid-lowering efficacy of a water dispersible formulation of free sterols versus plant sterol esters in humans consuming a supplemented dairy product
dc.contributor.author | Amir Shaghaghi, Mandana | |
dc.contributor.examiningcommittee | Mymin, David (Medicine) Moghadasian, Mohammad (Human Nutritional Sciences) Harding, Scott (Diabetes and Nutritional Sciences Division, King's College, London, United Kingdom) | en_US |
dc.contributor.supervisor | Jones, Peter (Human Nutritional Sciences, Food Sciences) | en_US |
dc.date.accessioned | 2012-04-04T17:30:56Z | |
dc.date.available | 2012-04-04T17:30:56Z | |
dc.date.issued | 2012-04-04 | |
dc.degree.discipline | Human Nutritional Sciences | en_US |
dc.degree.level | Master of Science (M.Sc.) | en_US |
dc.description.abstract | Reduced bioavailability in some formulations of phytosterols accounts for the variable results observed in LDL- C- lowering efficacy among trials. This study examined the effects of a water-dispersible formulation of free phytosterols (WD-PS) versus phytosterol esters (PS-esters) on plasma lipid and fat soluble vitamins concentrations in hypercholesterolemic individuals. Using a double-blind, randomized, crossover study, 47 hypercholesterolemics were provided for 4 wk: WD-PS-enriched yogurt (2g/d), PS-esters-enriched yogurt (2g/d), or yogurt alone (placebo), in a random order. Each study phase was separated by 4 wk washout intervals. Supplementation of WD-PS or PS-esters similarly decreased serum TC (7.7% and 6.3%, respectively) and LDL-C levels (11.7% and 11.6%, respectively, p<0.001). The ratio of TC/ HDL-C decreased for WD-PS (10.6%, p<0.05) but not for PS-esters. Moreover, WD-PS reduced serum TG (13.9%, p<0.05) as compared to PS-esters (0.6%). The results of the current study confirm the importance of the formulation of phytosterols in their bioavailability and efficacy. | en_US |
dc.description.note | May 2012 | en_US |
dc.identifier.uri | http://hdl.handle.net/1993/5255 | |
dc.language.iso | eng | en_US |
dc.rights | open access | en_US |
dc.subject | Esterified plant sterols | en_US |
dc.subject | Cholesterol absorption | en_US |
dc.subject | Water dispersible plant sterol | en_US |
dc.title | Evaluation of the lipid-lowering efficacy of a water dispersible formulation of free sterols versus plant sterol esters in humans consuming a supplemented dairy product | en_US |
dc.title.alternative | Water dispersible plant sterol formulation shows improved lipid lowering efficacy compared to plant sterol esters | en_US |
dc.type | master thesis | en_US |