Dynamic pathway analysis of genes associated with blood pressure using whole genome sequence data

Simple item page
dc.contributor.authorHu, Pingzhao
dc.contributor.authorPaterson, Andrew D
dc.date.accessioned2014-06-17T11:03:28Z
dc.date.available2014-06-17T11:03:28Z
dc.date.issued2014-06-17
dc.date.updated2014-06-17T11:03:29Z
dc.description.abstractAbstract Groups of genes assigned to a pathway, also called a module, have similar functions. Finding such modules, and the topology of the changes of the modules over time, is a fundamental problem in understanding the mechanisms of complex diseases. Here we investigated an approach that categorized variants into rare or common and used a hierarchical model to jointly estimate the group effects of the variants in a pathway for identifying enriched pathways over time using whole genome sequencing data and blood pressure data. Our results suggest that the method can identify potentially biologically meaningful genes in modules associated with blood pressure over time.
dc.description.versionPeer Reviewed
dc.identifier.citationBMC Proceedings. 2014 Jun 17;8(Suppl 1):S106
dc.identifier.doihttp://dx.doi.org/10.1186/1753-6561-8-S1-S106
dc.identifier.urihttp://hdl.handle.net/1993/23631
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderPingzhao Hu et al.; licensee BioMed Central Ltd.
dc.titleDynamic pathway analysis of genes associated with blood pressure using whole genome sequence data
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
1753-6561-8-S1-S106.xml
Size:
46.72 KB
Format:
Extensible Markup Language
Description:
Download
Thumbnail Image
Name:
1753-6561-8-S1-S106.pdf
Size:
522.82 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.17 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
University of Manitoba Scholarship
Rady Faculty of Health Sciences Scholarly Works