To improve the spectral efficiency while meeting the radio link level quality of service requirements such as the bit-error-rate (BER) requirements for the different wireless services, transmission rate and power corresponding to the different mobile users can be dynamically varied in a cellular wideband code-division multiple-access (WCDMA) network depending on the variations in channel interference and fading conditions. This paper models and analyzes the performance of transmission control protocol (TCP) under joint rate and power adaptation with constrained BER requirements for downlink data transmission in a cellular variable spreading factor (VSF) WCDMA network. The aim of this multilayer modeling of the WCDMA radio interface is to better understand the interlayer protocol interactions and identify suitable transport and radio link layer mechanisms to improve TCP performance in a wide-area cellular WCDMA network.