Secretory IgA: (Cross)linking Microbes, Maternal and Infant Health through Human Milk

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dc.contributor.authorDonald, Katherine
dc.contributor.authorPetersen, Charisse
dc.contributor.authorTurvey, Stuart
dc.contributor.authorFinlay, Brett
dc.contributor.authorAzad, Meghan
dc.date.accessioned2022-08-18T15:16:25Z
dc.date.available2022-08-18T15:16:25Z
dc.date.issued2022-05-11
dc.date.submitted2022-08-17T20:11:34Zen_US
dc.description.abstractSecretory Immunoglobulin A (SIgA) in human milk plays a central role in complex maternal-infant interactions that influence long term health outcomes. Governed by genetics and maternal microbial exposure, human milk SIgA shapes both the microbiota and immune system of the infant. Historically, SIgA-microbe interactions have been challenging to unravel due to their dynamic and personalized nature, particularly during early life. Recent advances have helped to clarify how SIgA acts beyond simple pathogen clearance to help guide and constrain a healthy microbiota, promote tolerance, and influence immune system development. In this review, we highlight these new findings in the context of the critical early-life window and propose outstanding areas of study that will be key to harnessing the benefits of SIgA to support healthy immune development in infancy.en_US
dc.description.sponsorshipMBA holds a Tier 2 Canada Research Chair in the Developmental Origins of Chronic Disease at the University of Manitoba and is a Fellow in the Canadian Institutes for Advanced Research (CIFAR) Humans and the Microbiome Program. She receives research funding from the Canadian Institutes of Health Research, Research Manitoba, the Canada Foundation for Innovation, the Bill and Melinda Gates Foundation, the Manitoba Children’s Hospital Foundation, Prolacta Biosciences, Mitacs, CIFAR, the Garfield Weston Foundation, Health Data Research UK, and Canadian COVID Immunity Task Force. She regularly speaks at conferences and workshops on infant nutrition, some sponsored by Prolacta Biosciences, and has spoken at a conference sponsored by AstraZeneca. She has contributed without remuneration to online courses on breast milk and the infant microbiome produced by Microbiome Courses. She serves in a volunteer capacity for the International Society for Research on Human Milk and Lactation and as a member of the National Academy of Sciences, Engineering and Medicine Committee on Scanning New Evidence on the Nutrient Content of Human Milk. She has consulted for DSM Nutritional Products and serves on the Malaika Vx Scientific Advisory Board.en_US
dc.identifier.doi10.1016/j.chom.2022.02.005
dc.identifier.urihttp://hdl.handle.net/1993/36706
dc.language.isoengen_US
dc.publisherCell Host & Microbeen_US
dc.rightsopen accessen_US
dc.subjectMaternal and Infant Healthen_US
dc.subjectHuman Milken_US
dc.subjectMicrobesen_US
dc.titleSecretory IgA: (Cross)linking Microbes, Maternal and Infant Health through Human Milken_US
dc.typepreprinten_US
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Pediatrics and Child Healthen_US
oaire.citation.endPage659en_US
oaire.citation.issue5en_US
oaire.citation.startPage650en_US
oaire.citation.titleCell Host & Microbeen_US
oaire.citation.volume30en_US
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