Expression of interleukin-6 (IL-6) in the cerebellum is not altered in the absence of Fragile X Mental Retardation Protein (FMRP) or with motor skill learning
| dc.contributor.author | Tabatabaei, Dina | |
| dc.contributor.examiningcommittee | Montgomery, Janine (Psychology) Marzban, Hassan (Human Anatomy and Cell Science) | en_US |
| dc.contributor.supervisor | Ivanco, Tammy (Psychology) | en_US |
| dc.date.accessioned | 2016-09-06T20:44:28Z | |
| dc.date.available | 2016-09-06T20:44:28Z | |
| dc.date.issued | 2016 | |
| dc.degree.discipline | Psychology | en_US |
| dc.degree.level | Master of Arts (M.A.) | en_US |
| dc.description.abstract | The ability of the brain to change structurally and functionally with experience is called brain plasticity. High levels of pro-inflammatory cytokines impair normal memory formation and consolidation. To better understand the role of pro-inflammatory cytokines in learning, the contribution of the cytokine interleukin-6 (IL-6) to a motor skill learning task investigated. The Fmr1 Knockout (KO) mouse, an animal model of Fragile X Syndrome, has demonstrated impaired neural plasticity and learning. Fmr1 KO and control wild-type (WT) mice were trained on the dowel and flat beam runways to study motor skill learning and motor activity respectively. The cerebellum from the animals was examined for IL-6 protein using ELISA. No significant differences in the levels of IL-6 in the cerebellum of the Fmr1 KO and WT normal mice were found. The expression of IL-6 was not altered by the behavioural training. These results suggest lack of association between IL-6, and FMRP and motor skill learning. | en_US |
| dc.description.note | October 2016 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/31638 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Fmr1 KO mice, IL-6, Motor Skill Learning, The Cerebellum | en_US |
| dc.title | Expression of interleukin-6 (IL-6) in the cerebellum is not altered in the absence of Fragile X Mental Retardation Protein (FMRP) or with motor skill learning | en_US |
| dc.type | master thesis | en_US |