The relative effects of tizanidine and baclofen on sensorimotor function in rats

dc.contributor.authorDe Haney, Suzanneen_US
dc.date.accessioned2007-05-18T20:03:27Z
dc.date.available2007-05-18T20:03:27Z
dc.date.issued2000-12-01T00:00:00Zen_US
dc.degree.disciplinePhysiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstract'Introduction'. Tizanidine, an (_2-noradrenergic/imidazoline agonist, and baclofen, a GABAb agonist, have been shown to have both antinociceptive and myorelaxant effects. In this study, the relative effect of tizanidine and baclofen on motor performance was tested at comparable analgesic dosages in rats. 'Methods'. Analgesia was measured using the tail-flick test and an analgesic index was calculated based on the cumulative increase in tail-flick latency. Motor performance was measured from kinematic analysis of swimming and a performance index was calculated based on the cumulative decrement in swim speed. Drugs, tizanidine and baclofen, were administered intraperitoneally following three baseline measurements at twenty minute intervals and subsequently monitored at regular twenty minute intervals for a period of two hours. Three comparable dosages were identified based on analgesia: low dose (0.5mg/kg tizanidine and 2.0 mg/kg baclofen), mid dose (1.5 mg/kg tizanidine and 5.0 mg/kg baclofen), and high dose(3.0 mg/kg tizanidine and 6.0 mg/kg baclofen. (Abstract shortened by UMI.)en_US
dc.format.extent5461252 bytes
dc.format.extent184 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.identifier.urihttp://hdl.handle.net/1993/1915
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.titleThe relative effects of tizanidine and baclofen on sensorimotor function in ratsen_US
dc.typemaster thesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
MQ57530.pdf
Size:
5.21 MB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
184 B
Format:
Plain Text
Description: