Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study

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dc.contributor.authorFerreira, Isabel
dc.contributor.authorCroca, Sara
dc.contributor.authorRaimondo, Maria G
dc.contributor.authorMatharu, Manjit
dc.contributor.authorMiller, Sarah
dc.contributor.authorGiles, Ian
dc.contributor.authorIsenberg, David
dc.contributor.authorIoannou, Yiannis
dc.contributor.authorHanly, John G
dc.contributor.authorUrowitz, Murray B
dc.contributor.authorAnderson, Nicole
dc.contributor.authorAranow, Cynthia
dc.contributor.authorAskanase, Anca
dc.contributor.authorBae, Sang-Cheol
dc.contributor.authorBernatsky, Sasha
dc.contributor.authorBruce, Ian N
dc.contributor.authorBuyon, Jill
dc.contributor.authorClarke, Ann E
dc.contributor.authorDooley, Mary A
dc.contributor.authorFortin, Paul
dc.contributor.authorGinzler, Ellen
dc.contributor.authorGladman, Dafna
dc.contributor.authorGordon, Caroline
dc.contributor.authorInanc, Murat
dc.contributor.authorJacobsen, Søren
dc.contributor.authorKalunian, Kenneth
dc.contributor.authorKamen, Diane
dc.contributor.authorKhamashta, Munther
dc.contributor.authorLim, Sam
dc.contributor.authorManzi, Susan
dc.contributor.authorMerrill, Joan
dc.contributor.authorNived, Ola
dc.contributor.authorPeschken, Christine
dc.contributor.authorPetri, Michelle
dc.contributor.authorRamsey-Goldman, Rosalind
dc.contributor.authorRuiz-Irastorza, Guillermo
dc.contributor.authorSanchez-Guerrero, Jorge
dc.contributor.authorSteinson, Kristjan
dc.contributor.authorSturfelt, Gunnar K
dc.contributor.authorvan Vollenhoven, Ronald
dc.contributor.authorWallace, Daniel J
dc.contributor.authorZoma, Asad
dc.contributor.authorRahman, Anisur
dc.date.accessioned2018-01-03T15:44:40Z
dc.date.available2018-01-03T15:44:40Z
dc.date.issued2017-12-22
dc.date.updated2018-01-01T08:59:42Z
dc.description.abstractAbstract Background In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE. Methods We obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and two matched controls with SLE but no NP events for each of these patients. For the NP patients we tested samples taken before, during and after the NP event. Results Twenty-six patients had events attributed to SLE according to the most stringent SLICC attribution rule. In these patients there was no association between onset of event and elevated serum NN. In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event (P = 0.006). The predominant clinical features in this group of 190 patients were headache, mood disorders and anxiety. Conclusions Serum NN levels rise at the time of an NP event in a proportion of patients with SLE. Further studies are needed to determine the value of serum NN as a biomarker for NPSLE.
dc.identifier.citationArthritis Research & Therapy. 2017 Dec 22;19(1):287
dc.identifier.urihttp://dx.doi.org/10.1186/s13075-017-1495-6
dc.identifier.urihttp://hdl.handle.net/1993/32726
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderThe Author(s).
dc.titleNitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study
dc.typeJournal Article
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