Exploring Novel Drug Treatments for Chemotherapy Resistance In Human Epithelial Ovarian Cancer (EOC)
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Date
2016
Authors
Moraya, Amani
Ali, Jennifer
Arthur, Gilbert
Schweizer, Frank
Werbowetski-Ogilvie, Tamra
Nachtigal, Mark
Morrison, Ludivine
Liang, Lisa
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Abstract
Chemotherapy resistance in human epithelial ovarian cancer (EOC) is a significant reason for the high rate of death among patients. We hypothesized that chemotherapy- resistant EOC cells will be killed by novel drug treatments in non-adherent culture conditions. The objective of this study was to test the efficacy of novel drugs to affect platinum resistant EOC cell viability. To achieve this, the cell killing efficacy of several drugs were tested on drug-resistant EOCs growing in non-adherent cultures. Both EOC cell lines and primary EOC cells isolated from patient ascites were used for these studies. Two different classes of drugs were tested including multikinase inhibitors (dorsomorphin and LDN-193189), and an understudied class of novel chemotherapeutic agents called glycosylated antitumor ether lipids (GAELs). EOC cells were treated with the drugs at different doses alone or in combination with cisplatin. Because GAELs exhibited promising results in resistant EOC cells, the mechanism of GAEL-induced cell-death was evaluated.
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Keywords
Exploring, Novel, Drug, Treatments, Chemotherapy, Resistance, Human, Epithelial, Ovarian, Cancer