A peel-able onion inspired multi-membrane chitosan hydrogel with reversible sol-gel transition, on-demanding dissolution for intestine-selective controlled release, shape memory, 3D printed E-skin biosensor and microchannel system

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Singh, Gurankit
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There are numerous properties of biomaterials, existing in the nature which are still unknown to the scientific community. Different modifications to the biomaterials can unlock new properties of these materials. This leads to the development of whole new type of material which can be used as an alternative to the existing materials and contribute to wide range of new applications. Stimuli-responsive hydrogels are one of the best strategies for controlled drug delivery, tissue engineering and biosensing based applications. Here in we report, a novel pH-sensitive and biodegradable hydrogel systems based on the carboxymethyl chitosan (CMC). The mechanical property of CMC changes from acidic to basic medium. This property is the reversible sol-gel conversion (solution phase to gel phase) of CMC solution based on the pH changes, and it was used in this work to synthesize peel-able onion like multimembrane hydrogels for a controlled fluorescein drug delivery model to intestine in gastro-intestine systems. Dissolution rates of the hydrogels was altered by using different concentrations of CMC and different number of hydrogels layers. Furthermore, CMC was used as a novel 3D printable bioink for potential biomaterial-based applications. The resulting CMC 3D printed structures were further used as a real-time wireless biosensor and for designing microfluidic channels. The mechanical properties and characterization of the CMC were studied by using rheology tests, FT-IR and 1H NMR.
Chitosan, peel-able onion-like multi-membrane gel, shape memory, reversible sol-gel, 3D printing bioink, microfluidics, gastric-intestine controlled release