Placental pathology correlation to fetal and neonatal diagnostic outcomes in a cohort of infants admitted in a newborn high risk follow-up program

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Schanbacher, David
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This study is designed to investigate the nature of pathologically significant placentas and their corresponding fetal and neonatal outcomes in term infants. We aim to examine the correlation between specific placental pathologies and neonatal clinical conditions, including brain injury, requiring admission to a neonatal care unit and subsequent follow-up in our High Risk Newborn Follow-up Program (HRFU). A retrospective cohort study was conducted through review of maternal and neonatal reports. Overall 48 neonates had placentas submitted for examination. Sixty-one percent of placentas in the HRFU group and 62% of placentas in the non-HRFU group had findings consistent with ischemic changes, meconium staining and calcifications. Three infants had hypoxic ischemic encephalopathy. This study found no difference in placental pathology between non-HRFU infants and infants enrolled in the HRFU Program. This raises questions and warrants further study on the efficacy for placental submission as a predictive measure for neonatal outcomes.
Placenta, High Risk