Monofunctional platinum(ii) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks

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Date
2020-04-20Author
Lozada, Issiah
Huang, Bin
Stilgenbauer, Morgan
Beach, Travis
Qiu, Zihan
Zheng, Yaorong
Herbert, David E
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Phenanthriplatin is a leading preclinical anticancer Pt complex distinguished by a phenanthridine ligand that facilitates DNA-targeted covalent binding via intercalation. We report here that Pt(II) complexes incorporating phenanthridine into a chelating, multidentate ligand scaffold exhibit a superior in vitro therapeutic index compared with phenanthriplatin and cisplatin.