Monofunctional platinum(ii) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks

Thumbnail Image
Date
2020-04-20
Authors
Lozada, Issiah
Huang, Bin
Stilgenbauer, Morgan
Beach, Travis
Qiu, Zihan
Zheng, Yaorong
Herbert, David E
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
Phenanthriplatin is a leading preclinical anticancer Pt complex distinguished by a phenanthridine ligand that facilitates DNA-targeted covalent binding via intercalation. We report here that Pt(II) complexes incorporating phenanthridine into a chelating, multidentate ligand scaffold exhibit a superior in vitro therapeutic index compared with phenanthriplatin and cisplatin.
Description
Keywords
chemotherapeutics, Coordination Chemistry
Citation
Dalton Transactions, 2020, 49, 6557-6560