Predicting complicated Crohn’s disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population based cohort

Show simple item record

dc.contributor.author Ryan, John David
dc.contributor.author Silverberg, Mark
dc.contributor.author Xu, Wei
dc.contributor.author Graff, Lesley A.
dc.contributor.author Targownik, Laura
dc.contributor.author Walker, John R.
dc.contributor.author Carr, Rachel
dc.contributor.author Clara, Ian
dc.contributor.author Miller, Norine
dc.contributor.author Rogala, Linda
dc.contributor.author Bernstein, Charles N.
dc.date.accessioned 2015-05-11T17:28:42Z
dc.date.available 2015-05-11T17:28:42Z
dc.date.issued 2012-08
dc.identifier.citation Aliment Pharmacol Ther. 2013 Aug;38(3):274-83 en_US
dc.identifier.uri http://hdl.handle.net/1993/30418
dc.description.abstract BACKGROUND: Predictors of complicated Crohn's disease (CD), defined as stricturing or penetrating behaviour, and surgery have largely been derived from referral centre populations. AIM: To investigate whether serological markers, susceptibility genes or psychological characteristics are associated with complicated CD or surgery in a population-based cohort. METHODS: One hundred and eighty-two members of the Manitoba IBD Cohort with CD phenotyped using the Montreal classification underwent genetic and serological analysis at enrolment and after 5 years. One hundred and twenty-seven had paired sera at baseline and 5 years later and their data were used to predict outcomes at a median of 9.3 years. Serological analysis consisted of a seven antibody panel, and DNA was tested for CD-associated NOD2 variants (rs2066845,rs2076756,rs2066847), ATG16L1 (rs3828309, rs2241880) and IL23R (rs11465804). Psychological characteristics were assessed using semi-structured interviews and validated survey measures. RESULTS: Sixty-five per cent had complicated CD and 42% underwent surgery. Multivariate analysis indicated that only ASCA IgG-positive serology was predictive of stricturing/penetrating behaviour (OR = 3.01; 95% CI: 1.28-7.09; P = 0.01) and ileal CD (OR = 2.2; 95% CI: 1.07-4.54, P = 0.03). Complicated CD behaviour was strongly associated with surgery (OR = 5.6; 95% CI: 2.43-12.91; P < 0.0001), whereas in multivariate analysis, only ASCA IgG was associated (OR = 2.66; 95% CI, 1.40-5.06, P = 0.003). ASCA titre results were similar at baseline and follow-up. Psychological characteristics were not significantly associated with disease behaviour, serological profile or genotype. CONCLUSIONS: ASCA IgG at baseline was significantly associated with stricturing/penetrating disease at 9-10 years from diagnosis. Stricturing/penetrating disease was significantly associated with surgery. In a model including serology, the genotypes assessed did not significantly associate with complicated disease or surgery. en_US
dc.language.iso en en_US
dc.publisher Alimentary Pharmacology and Therapeutics en_US
dc.relation.ispartofseries 38(3);274-83
dc.rights info:eu-repo/semantics/openAccess
dc.subject Complicated en_US
dc.subject Crohn's Disease en_US
dc.subject surgery en_US
dc.subject phenotypes en_US
dc.subject genetics en_US
dc.subject Bernstein en_US
dc.title Predicting complicated Crohn’s disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population based cohort en_US
dc.type Article en_US
dc.type Dataset en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi 10.1111/apt.12368

Files in this item

This item appears in the following Collection(s)

  • Research Publications [1211]
    This collection contains full text research publications authored or co-authored by University of Manitoba researchers.

Show simple item record

View Statistics