• Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls 

  Kim, Julian O.; Balshaw, Robert; Trevena, Connel; Banerji, Shantanu; Murphy, Leigh; Dawe, David; Tan, Lawrence; Srinathan, Sadeesh; Buduhan, Gordon; Kidane, Biniam; Qing, Gefei; Domaratzki, Michael; Aliani, Michel (2022-10-12)

  Abstract Background Metabolomics is a potential means for biofluid-based lung cancer detection. We conducted a non-targeted, data-driven assessment of plasma from early-stage ...

• Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update 

  Bennett, Alexandria; Beck, Andrew; Shaver, Nicole; Grad, Roland; LeBlanc, Allana; Limburg, Heather; Gray, Casey; Abou-Setta, Ahmed; Klarenbach, Scott; Persaud, Navindra; Thériault, Guylène; Thombs, Brett D.; Todd, Keith J.; Bell, Neil; Dahm, Philipp; Loblaw, Andrew; Del Giudice, Lisa; Yao, Xiaomei; Skidmore, Becky; Rolland-Harris, Elizabeth; Brouwers, Melissa; Little, Julian; Moher, David (2022-10-26)

  Abstract Purpose To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening for prostate cancer in adults aged 18 years and older in ...

• Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data 

  Hughes, Sean M.; Levy, Claire N.; Katz, Ronit; Lokken, Erica M.; Anahtar, Melis N.; Hall, Melissa B.; Bradley, Frideborg; Castle, Philip E.; Cortez, Valerie; Doncel, Gustavo F.; Fichorova, Raina; Fidel, Paul L.; Fowke, Keith R.; Francis, Suzanna C.; Ghosh, Mimi; Hwang, Loris Y.; Jais, Mariel; Jespers, Vicky; Joag, Vineet; Kaul, Rupert; Kyongo, Jordan; Lahey, Timothy; Li, Huiying; Makinde, Julia; McKinnon, Lyle R.; Moscicki, Anna-Barbara; Novak, Richard M.; Patel, Mickey V.; Sriprasert, Intira; Thurman, Andrea R.; Yegorov, Sergey; Mugo, Nelly R.; Roxby, Alison C.; Micks, Elizabeth; Hladik, Florian (2022-10-05)

  Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, ...

• Evaluation of factors that influenced the length of hospital stay using data mining techniques 

  Eskandari, Mehrnoosh; Alizadeh Bahmani, Amir H.; Mardani-Fard, Heydar A.; Karimzadeh, Iman; Omidifar, Navid; Peymani, Payam (2022-10-29)

  Abstract Background length of stay (LOS) is the time between hospital admission and discharge. LOS has an impact on hospital management and hospital care functions. ...

• Birth registration coverage according to the sex of the head of household: an analysis of national surveys from 93 low- and middle-income countries 

  Wendt, Andrea; Hellwig, Franciele; Saad, Ghada E.; Faye, Cheikh; Boerma, Ties; Barros, Aluisio J. D.; Victora, Cesar G. (2022-10-19)

  Abstract Background Within-country inequalities in birth registration coverage (BRC) have been documented according to wealth, place of residence and other household ...

• Evaluation of baseline pediatric readiness of emergency departments in Manitoba, Canada 

  Aregbesola, Alex; Florescu, Oana; Tam, Clara; Coyle, Amanda; Knisley, Lisa; Hogue, Kaitlin; Beer, Darcy; Sawyer, Scott; Klassen, Terry P. (2022-10-10)

  Abstract Background Data on the readiness of the general emergency departments (EDs) in Canada to care for children requiring emergency care are limited. Recent evidence ...

• vACcine COnfidence amongst those living with alleRgy during the COVID pandemic (ACCORD): a scoping review protocol 

  Golding, Michael A.; Askin, Nicole; Batac, Ayel L. R.; Merrill, Kaitlyn A.; Abrams, Elissa M.; Bégin, Philippe; Ben-Shoshan, Moshe; Ladouceur, Erika; Roos, Leslie E.; Protudjer, Vladan; Protudjer, Jennifer L. P. (2022-09-18)

  Abstract Background Reports of allergic reactions to the COVID-19 vaccines have been documented, which may also contribute to hesitancy. Despite the low likelihood that the ...

• Correction: Building Emotional Awareness and Mental Health (BEAM): study protocol for a phase III randomized controlled trial of the BEAM app-based program for mothers of children 18–36 months 

  Xie, E. B.; Simpson, Kaeley M.; Reynolds, Kristin A.; Giuliano, Ryan J.; Protudjer, Jennifer L. P.; Soderstrom, Melanie; Sauer-Zavala, Shannon; Giesbrecht, Gerald F.; Lebel, Catherine; Mackinnon, Anna L.; Rioux, Charlie; Penner-Goeke, Lara; Freeman, Makayla; Salisbury, Marlee R.; Tomfohr-Madsen, Lianne; Roos, Leslie E. (2022-09-30)

• Building Emotional Awareness and Mental Health (BEAM): study protocol for a phase III randomized controlled trial of the BEAM app-based program for mothers of children 18–36 months 

  Xie, E. B.; Simpson, Kaeley M.; Reynolds, Kristin A.; Giuliano, Ryan J.; Protudjer, Jennifer L. P.; Soderstrom, Melanie; Sauer-Zavala, Shannon; Giesbrecht, Gerald F.; Lebel, Catherine; Mackinnon, Anna L.; Rioux, Charlie; Penner-Goeke, Lara; Freeman, Makayla; Salisbury, Marlee R.; Tomfohr-Madsen, Lianne; Roos, Leslie E. (2022-09-05)

  Abstract Background The prevalence of maternal depression and anxiety has increased during the COVID-19 pandemic, and pregnant individuals are experiencing concerningly elevated ...

• Emergency contraception subsidy in Canada: a comparative policy analysis 

  Lee, Sabrina C.; Norman, Wendy V. (2022-09-01)

  Abstract Background In Canada, cost prohibits access to emergency contraception (EC) which may assist to prevent unintended pregnancy. The drug, ulipristal acetate (UPA-EC), ...

• Building capacity for integrated knowledge translation: a description of what we can learn from trainees’ experiences during the COVID-19 pandemic 

  Medeiros, Priscilla; Laur, Celia; Nguyen, Tram; Gilfoyle, Meghan; Conway, Aislinn; Giroux, Emily; Hoekstra, Femke; Legasto, Jean M.; Ramage, Emily; Tittlemier, Brenda; Wood, Brianne; Steinwender, Sandy (2022-09-15)

  Abstract The use of collaborative health research approaches, such as integrated knowledge translation (IKT), was challenged during the COVID-19 pandemic due to physical distancing measures and transition to ...

• COVID-19 pandemic or chaos time management: first-line worker shortage – a qualitative study in three Canadian Provinces 

  Beogo, Idrissa; Bationo, Nebila J.; Sia, Drissa; Collin, Stephanie; Kinkumba Ramazani, Babou; Létourneau, Aurée-Anne; Ramdé, Jean; Gagnon, Marie-Pierre; Tchouaket, Eric N. (2022-09-03)

  Abstract Background Over the successive waves of the COVID-19 pandemic, front-line care workers (FLCWs) —in this case, at long-term care facilities (LTCFs)— have been the ...

• Three-dimensional nuclear telomere architecture and differential expression of aurora kinase genes in chronic myeloid leukemia to measure cell transformation 

  de Oliveira, Fábio M.; Jamur, Valderez R.; Merfort, Lismeri W.; Pozzo, Aline R.; Mai, Sabine (2022-09-29)

  Abstract Background Telomere dysfunction results in aneuploidy, and ongoing chromosomal abnormalities. The three-dimensional (3D) nuclear organization of telomeres allows for ...

• Paramedic attitudes towards prehospital spinal care: a cross-sectional survey 

  McDonald, Neil; Kriellaars, Dean; Pryce, Rob T. (2022-09-20)

  Abstract Background The optimal application of spinal motion restriction (SMR) in the prehospital setting continues to be debated. Few studies have examined how changing ...

• Implementation and facilitation of post-resuscitation debriefing: a comparative crossover study of two post-resuscitation debriefing frameworks 

  Kam, April J.; Gonsalves, Clarelle L.; Nordlund, Samantha V.; Hale, Stephen J.; Twiss, Jennifer; Cupido, Cynthia; Brar, Mandeep; Parker, Melissa J. (2022-09-02)

  Abstract Background Post-resuscitation debriefing (PRD) is the process of facilitated, reflective discussion, enabling team-based interpersonal feedback and identification of ...

• Characteristics of new users of recent antidiabetic drugs in Canada and the United Kingdom 

  Brunetti, Vanessa C.; St-Jean, Audray; Dell’Aniello, Sophie; Fisher, Anat; Yu, Oriana H. Y.; Bugden, Shawn C.; Daigle, Jean-Marc; Hu, Nianping; Alessi-Severini, Silvia; Shah, Baiju R.; Ronksley, Paul E.; Lix, Lisa M.; Ernst, Pierre; Filion, Kristian B. (2022-09-29)

  Abstract Background Characteristics of patients using newer 2nd and 3rd line antidiabetic drugs in a real-world setting are poorly understood. We described the characteristics ...

• Public health genomics capacity assessment: readiness for large-scale pathogen genomic surveillance in Canada’s public health laboratories 

  Nadon, C.; Croxen, M.; Knox, N.; Tanner, J.; Zetner, A.; Yoshida, C.; Van Domselaar, G. (2022-09-24)

  Abstract Background Along with rapid diagnostic testing, contact tracing, and public health measures, an effective pandemic response incorporates genomics-based surveillance. ...

• Canadian Veteran chronic disease prevalence and health services use in the five years following release: a matched retrospective cohort study using routinely collected data 

  Mahar, Alyson L.; Cyr, Kate S.; Enns, Jennifer E.; Aiken, Alice B.; Whitehead, Marlo; Cramm, Heidi; Kurdyak, Paul (2022-09-05)

  Abstract Background Occupational exposures may result in Canadian military Veterans having poorer health and higher use of health services after transitioning to civilian life ...

• Frontotemporal Dementia-related glucose metabolic pattern assessed by FDG-PET 

  Lau, Angus (2020-08-06)

  Alzheimer's disease (AD) and Frontotemporal Dementia (FTD) are leading causes of dementia.

• Investigation of the Disease Manifestations and Genetics of a novel TDP1 Mutation, the gene implicated in Spinocerebellar Ataxia with Axonal Neuropathy 1 (SCAN1) 

  Janes, Alvin (2020-08-06)

  Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a protein best-characterized in its DNA repair role via resolution of stalled Topoisomerase1-DNA (TOP1-DNA) complexes. These stalled complexes would otherwise collide with DNA ...

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