Prevalence of Hypogammaglobulinemia in the Indigenous Population with Bronchiectasis in Manitoba
| dc.contributor.author | Grenier, Liam | |
| dc.contributor.supervisor | Kalicinsky, Chrystyna | |
| dc.contributor.supervisor | Zaborniak, Karver | |
| dc.date.accessioned | 2023-11-21T20:46:14Z | |
| dc.date.available | 2023-11-21T20:46:14Z | |
| dc.date.issued | 2022-08-04 | |
| dc.date.submitted | 2023-11-21T20:46:14Z | en_US |
| dc.degree.discipline | Medicine | en_US |
| dc.degree.level | Bachelor of Science in Medicine (B.Sc.Med.) | |
| dc.description.abstract | Bronchiectasis is a obstructive lung disease characterized by irreversible dilation of airways, inflammation, chronic lower airway infection, and destruction of bronchial walls. An often overlooked condition that contributes to bronchiectasis development is hypogammaglobulinemia. Thus, quantification of immunoglobulin should be measured when evaluating bronchiectasis patients. Bronchiectasis is highly prevalent in Manitoba’s Indigenous population; this is likely due to high rates of tuberculosis. Despite this, Indigenous patients are underrepresented at the Clinical Immunology Clinic at the Health Sciences Center. The goal of this study was to evaluate if immunoglobulin levels are being tested in Indigenous patients with bronchiectasis and identify gaps in care provided to Indigenous patients with bronchiectasis in Manitoba. This was a retrospective chart review; comparison was between two groups of age and sex-matched patients with bronchiectasis in Manitoba, one of non-Indigenous patients and one Indigenous as determined from Accuro EMR used at HSC outpatient clinics. Quantitative immunoglobulins were reviewed and the frequency of hypogammaglobulinemia in the two groups were compared. Of the 145 patients identified in the chart review, approximately 55% had immunoglobulin results available. Although the true prevalence of hypogammaglobulinemia in Indigenous Manitobans with bronchiectasis could not be determined, statistical analysis revealed social and medical factors that affected the likelihood of a participant having immunoglobulin levels tested. Area of residence and tuberculosis status were found to be significant predictors of antibody testing. The findings of this study can be used to further our understanding of hypogammaglobulinemia prevalence in bronchiectasis patients as well as improve treatment of the disease. | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/37802 | |
| dc.language.iso | eng | |
| dc.rights | open access | en_US |
| dc.subject | Bronchiectasis | |
| dc.title | Prevalence of Hypogammaglobulinemia in the Indigenous Population with Bronchiectasis in Manitoba | |
| dc.type | bachelor thesis | en_US |
| local.author.affiliation | Rady Faculty of Health Sciences::Max Rady College of Medicine::Department of Internal Medicine |