The DISCERN (Discovering Innovative Strategies for prevention of delirium in Cardiac surgery patients through Evaluation of peri-operative Risk and Novel biomarkers) Study – Intermediate and long-term follow up of post-operative health-related quality of life and mental health status.
| dc.contributor.author | Nguyen, Quyen | |
| dc.date.accessioned | 2015-06-01T19:38:30Z | |
| dc.date.available | 2015-06-01T19:38:30Z | |
| dc.date.issued | 2015-08-08 | |
| dc.description.abstract | Delirium is an acute form of “brain failure” characterized by fluctuation of attention and cognition. It is the most common neurological complication following cardiac surgery. The incidence of post-operative delirium in surgical patients varies between 10-60%, but can be as high as 73% in the elderly. Our study objectives were: 1) to examine the effect of post-operative delirium on mid- to long-term health-related quality of life (HRQoL) in patients following cardiac surgery, 2) to examine the effect of post-operative delirium on mental health following cardiac surgery and 3) to determine risk factors for each of these conditions. A prospective observational cohort study was carried out at a tertiary care centre in Winnipeg, Manitoba. Within the study cohort of 197 patients, the rate of post-operative delirium was 21.1% in elective cardiac surgery patients and 30.8% in urgent or emergent patient. Preoperative predictors of post-operative delirium were higher EuroSCORE II, previous cardiovascular procedure, older age, less than high school education and left ventricular ejection fraction of <35%. Intra-operative predictors of post-operative delirium were increased cardiopulmonary pump time, acute kidney injury, returning to the OR due to post-operative bleeding and new cerebrovascular accident. Delirious patients remained in the ICU almost 4 times longer than non-delirious patients and were hospitalized on average 5 days longer. Patients who suffered from post-operative delirium were 2 times more likely to score below average in the physical health aspect of the SF-12v2 and were nearly 3 times more likely to report having a problem with anxiety or depression. | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/30549 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | DISCERN | en_US |
| dc.title | The DISCERN (Discovering Innovative Strategies for prevention of delirium in Cardiac surgery patients through Evaluation of peri-operative Risk and Novel biomarkers) Study – Intermediate and long-term follow up of post-operative health-related quality of life and mental health status. | en_US |
| dc.type | Other | en_US |