Inflammatory pattern in HIV patients with Community acquired pneumonia and it's relationship with pulmonary dysfunction.

Simple item page
dc.contributor.authorMao, Tony
dc.date.accessioned2018-10-03T16:17:58Z
dc.date.available2018-10-03T16:17:58Z
dc.date.issued2018-08-23
dc.date.submitted2018-10-03T16:17:58Zen
dc.description.abstractPrior studies have shown that HIV patients develop permanent pulmonary dysfunction following an episode of community acquired pneumonia (CAP). However, the mechanism causing pulmonary dysfunction remains an enigma. HIV patients experience chronic inflammation. We hypothesized that CAP infection worsens inflammation in HIV patients which leads to an accelerated decline in pulmonary function. A prospective cohort pilot study was performed, participants include patients hospitalized in Hospital Universitario San Vicente Fundación and Clínica SOMA, in Medellín, Colombia. Sixteen patients were eligible for the study, they were split into two groups: HIV and HIV+CAP. Plasma, sputum and pulmonary function test (PFT) measurements were retrieved within 48 hours of hospital admission and at one month follow-up. The concentrations of 13 molecules and PFT values were compared between the two cohorts. HIV+CAP group demonstrated a decline in pulmonary function compared to the HIV group, FVC%predicted and FEV1%predicted decreased while FEV1/FVC remained constant. APRIL, BAFF and TIMP-1 trended towards higher concentrations in the HIV+CAP group compared to the HIV group. These three molecules correlated negatively with FVC%predicted and FEV1%predicted, they have the potential to serve as biomarkers for predicting pulmonary dysfunction. Furthermore, the concentrations of BAFF, CCL3 and TIMP-1 were statistically significant between the two groups (=0.05). These molecules are involved in inflammation response in humans. We speculate that abnormal expression of these molecules may play a role in dysregulating inflammatory response, which leads to pulmonary dysfunction. These results need to be replicated with larger cohorts and longer follow-up time (to assess for permanent pulmonary dysfunction).en_US
dc.description.sponsorshipH.T. Thorlakson Foundation Dean, College of Medicine Research Manitoba Manitoba Medical Service Foundation (MMSF) Vice-Dean, Research Rady FHS Health Sciences Centre Research Foundation Heart and Stroke Foundationen_US
dc.identifier.citationAMAen_US
dc.identifier.urihttp://hdl.handle.net/1993/33516
dc.rightsopen accessen_US
dc.subjectcommunity acquired pneumonia (CAP)en_US
dc.subjectHIVen_US
dc.subjectpulmonary function test (PFT)en_US
dc.subjectpulmonary dysfunctionen_US
dc.titleInflammatory pattern in HIV patients with Community acquired pneumonia and it's relationship with pulmonary dysfunction.en_US
dc.typebachelor thesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Mao_BSc(Med) Report.pdf
Size:
1.65 MB
Format:
Adobe Portable Document Format
Description:
BSc(Med) Final Research Report
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
College of Medicine - B.Sc. (Med) Projects