Intraoperative prediction of cardiac surgery-associated acute kidney injury
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Date
2015-08-07
Authors
Crosina, Jordan
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Abstract
Cardiac surgery associated acute kidney injury (CSA-AKI) is a potentially lethal complication which
occurs in up to 30% of cardiac surgery patients. When the injury is severe enough to necessitate dialysis
(which occurs in approximately 1% to 2% of patients) it confers a 19-fold increase in the odds of death.
Even when the injury is relatively modest (i.e. a 25 % rise in postoperative serum creatinine), it is
independently associated with morbidity and mortality.
A major barrier to preventing CSA-AKI is the lack of available strategies for early detection of kidney
injury. Work done by our team has established Hepcidin-25 as a novel urine biomarker of CSA-AKI.
Newer data suggest NGAL, OSMR, MMP-2, and Klotho are also potential early biomarkers of CSAAKI.
Objective: To study the value of 5 urine and serum biomarkers in the diagnosis of incipient CSA-AKI. A
unique and novel aspect of our project will be assessing the value of intraoperative measurements of
these biomarkers.
Design: Prospective cohort study of 350 cardiac surgery patients (280 patients have already been
recruited)
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Keywords
acute kidney injury, cardiac surgery, CSA-AKI