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Mechanism of hydrolysis-activation of the cardioprotective antioxidant dexrazoxane and identification of more effective analogs by development of a quantitative structure-activity relationship describing imide hydrolysis
(1998-01-01)
Dexrazoxane reduces the cardiotoxicity of anthracyclines, without affecting its antitumor activity. Doxorubicin-induced cardiomyopathy is thought to be due to iron-based oxidative stress. Dexrazoxane is thought to act by ...
A study of a chiral 4-substituted oxazolidin-2-one in asymmetric transformations via soluble polymer-supported synthesis and fluorous synthesis
(1999-07-01)
Chiral auxiliaries remain one of the most reliable ways of generating new chiral molecules in a highly enantiomerically enriched form. We have synthesized a new chiral -substituted oxazolidin-2-one from ' L'-tyrosine via ...
Studies in the synthesis of mechanism-based steroid enzyme inhibitors and related compounds
(1997-10-01)
The main goal of the thesis was to synthesize compounds which would selectively inhibit a function of steroid enzymes. Three enzymes have been targeted; 3$\alpha,20\beta$- (EC 1.1.1.53) and 17$\beta,20\alpha$-hydroxy ...
Asymmetric induction using methyl (S)-lactate and application to the synthesis of Bao Gong Teng A
(1997-06-01)
An example of an stereoselective reaction is illustrated by the reduction of optically pure (3S)-3-tert-butylcyclohexanone, (S)-1 as shown in Scheme 1.* The reduction generates a new chiral center at C1, forming (3S,1R)-2 ...
Magnetic resonance perfusion imaging and double quantum coherence transfer magnetic resonance spectroscopy
(1999-08-01)
The thesis is composed of two parts. Magnetic resonance (MR) perfusion imaging using continuous arterial spin tagging (CAST) and double quantum (DQ) coherence transfer MR spectroscopy (MRS) are the main themes respectively. ...
Controlled molecular design and polymerization of polyaromatic ethers
(1997-08-01)
This is the first study where the number of Fe$\sp{+}$Cp moieties pendant to the backbone of polyaromatic materials could be controlled in a manner such that materials with 2-35 metal moieties were prepared. The efficiency ...
Characterization of sugars and glycans from ovalbumin using a combination of derivatization, high-performance liquid chromatography and mass spectrometry
(1998-12-01)
A combination of derivatization, reversed-phase high performance liquid chromatography (RP-HPLC), and mass spectrometry techniques has been explored for the characterization of small sugars, medium-size oligosaccharide , ...
The mass spectrometric characterization of polychlorinated n-alkanes and the methodology for their analysis in the environment
(1997-06-01)
The major objective of the research was to develop a method for sensitive and specific analysis of C$\sb{10}$-C$\sb{13}$ polychloroalkanes (PCAs) in environmental samples. Our method of choice became high resolution gas ...
The synthesis of enantiomerically pure aryltetralin lignans
(1997-09-11)
The preparation of enantiomerically pure aryltetralin lignans has been accomplished using both a Diels-Alder approach and a newer oxidative free radical coupling/cyclization. Past research established that aryltetralins ...
The separation and isolation of metals using polyurethane materials
(1998-05-01)
Membranes made of polyurethane have shown the ability to quantitatively extract and transport certain metal complexes from one solution to another. The transport of the metals can be controlled using appropriate solution ...