The Next Generation Cohort: Childhood Outcomes of Offspring of Parents with Early Onset Type 2 Diabetes

Abstract

The Next Generation Birth Cohort has recruited 127 offspring of parents with youth-onset type 2 diabetes (T2DM)since 2003. Despite the high rate of awareness of the risks of obesity and T2DM in the offspring, 66% are obese at the most recent assessment with an average BMI zscore of 1.9, and 34.4% of the offspring age 10 years and older have T2DM. All of the offspring . with T2DM are overweight or obese, all were born to mothers with pre-pregnancy T2DM, and all have 1 or 2 copies ofthe private HNF-l a G319S polymorphism. The size of the cohort remains too small to make conclusions about the impact of the intrauterine environment and the S319 allele on the risk ofT2DM in this highly selected population.