• Libraries
    • Log in to:
    View Item 
    •   MSpace Home
    • Rady Faculty of Health Sciences
    • College of Medicine - B.Sc. (Med) Projects
    • View Item
    •   MSpace Home
    • Rady Faculty of Health Sciences
    • College of Medicine - B.Sc. (Med) Projects
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Gefitinib as a Potential Treatment for Aggressive CLL

    Thumbnail
    View/Open
    Liu_E_BScMed_2011.pdf (244.0Kb)
    Date
    2012-03-12
    Author
    Liu, Elaine
    Metadata
    Show full item record
    Abstract
    Chronic lymphocytic leukemia (CLL) is presently an incurable disease that is expected to increase in prevalence, as a result of the aging population. Currently, the standard treatment used is chlorambucil or fludarabine, combined with cyclophosphamide and rituximab. The disease has a variable course. Recently, it has been shown that the expression of the tyrosine kinase, ZAP-70 in CLL is a strong indicator of poor prognosis, with a greatly reduce time to treatment from diagnosis, compared with ZAP-70 negative patients. Therefore, therapy that specifically targets ZAP-70 positive CLL might improve these patients’ outcomes. The tyrosine kinase inhibitor gefitinib has been shown to reduce the phosphorylation levels of several tyrosine kinases including ZAP-70 and SYK. We treated several ZAP-70 positive and ZAP-70 negative patient samples with gefitinib and found that gefitinib had a much lower IC 50 for ZAP-70 positive patients than it did for ZAP-70 negative patients. Also, gefitinib induced more apoptosis in the ZAP-70 positive cell line Jurkat than it did in cells lines not expressing ZAP-70. These results support a role for gefitinib in the treatment of ZAP-70 positive CLL.
    URI
    http://hdl.handle.net/1993/5174
    Collections
    • College of Medicine - B.Sc. (Med) Projects [206]

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of MSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV