Search
Now showing items 1-10 of 41
Supportive care in the management of severe pneumonia in Nigerian children
(2012-03-12)
According to 2008 estimates, about 177,000 children under the age of five years died of
pneumonia in Nigeria, which was the third commonest cause of the 1 million deaths in
Nigerian under-5s. Detecting hypoxemia with the ...
The Prognostic Value of Cystatin C and Urinary NGAL in Patients With the Cardiorenal Syndrome
(2012-03-12)
Congestive heart failure (CHF) is a common disease and leads to numerous deaths in
Canada annually. Part of the reason is due to the high prevalence of renal dysfunction in
this patient population, a comorbidity that ...
Factors and signals regulating expression of the pro-hypertrophic, high molecular weight FGF-2, by human cardiac myofibroblasts
(2012-03-12)
Bacl{gl'Ound. Chronic activation of the renin-aogiotensin-aldosterone axis causes
maladaptive cardiac remodeling leading to heart failure. This is partially due to the conversion of
cardiac fibroblasts to an 'activated' ...
Antihypertensive medications and cancer patient survival: A populationbased retrospective cohort study
(2012-03-12)
Rationale: The relationship between antihypertensive medications and cancer development has
been widely studied. There is extensive in vitro evidence for a beneficial effect for beta-blocker
drugs in particular. ...
The Next Generation Cohort: Childhood Outcomes of Offspring of Parents with Early Onset Type 2 Diabetes
(2012-03-12)
The Next Generation Birth Cohort has recruited 127 offspring of parents with youth-onset type 2
diabetes (T2DM)since 2003. Despite the high rate of awareness of the risks of obesity and
T2DM in the offspring, 66% are ...
The impact of donor and recipient age-related factors on long-tenn haematopoietic potential and telomere length following allogeneic haematopoietic progenitor cell transplant
(2012-03-12)
OBJECTNE: Advanced donor and recipient age-related factors negatively impact outcomes of
haematopoietic progenitor cell (HPC) transplant. Telomere shortening, which occurs due to rapid
HPC proliferation during the ...
The Accuracy of Clinical Criteria to Predict Mutations in BRCA1- and BRCA2-Related Hereditary Breast and Ovarian Cancer Syndrome
(2012-03-12)
The Hereditary Breast and Ovarian Cancer (HBOC) Clinic located in Winnipeg accepts province-wide referrals to assess cancer risk and provide testing for mutations in BRCA1 and BRCA2 when indicated. Given the economic ...
Fish Oil Mediated Cardiovascular Complications in ApoEKO Mice
(2012-03-12)
BACKGROUND: Atherosclerosis is the principle cause of cardiovascular disease. Due to their spontaneous development of atherosclerosis, apolipoprotein E knockout mice (ApoEKO) are one of the best studied animal models of ...
Does loss of AKAP121 precede induction of cardiac hypertrophy?
(2012-03-12)
The A‐kinase anchor proteins (AKAPs) are diverse regulators of cell function, acting as scaffolds
to co‐localize the protein kinase A regulatory sub‐unit with target proteins, such as other
kinases and phosphatases. We ...
Mental Health Issues Associated with Foot Complications of Diabetes Mellitus
(2012-03-12)
Diabetes mellitus (DM) is a chronic disease associated with severe multi-system
complications including, but not exclusive to, peripheral neuropathy, peripheral vascular disease,
renal and cardiovascular disease. Diabetic ...