• Libraries
    • Log in to:
    View Item 
    •   MSpace Home
    • Faculty of Graduate Studies (Electronic Theses and Practica)
    • FGS - Electronic Theses and Practica
    • View Item
    •   MSpace Home
    • Faculty of Graduate Studies (Electronic Theses and Practica)
    • FGS - Electronic Theses and Practica
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Transcriptional regulation of the retinoblastoma family member p107 by Dlx homeobox genes during central nervous system development

    Thumbnail
    View/Open
    zagozewski_jamie.pdf (30.50Mb)
    Date
    2012-01-11
    Author
    Zagozewski, Jamie Lauren
    Metadata
    Show full item record
    Abstract
    Objective: The absence of Dlx1/Dlx2 results in defects in neural differentiation and migration in the developing forebrain and retina. To further understand genetic regulation of neural differentiation and migration by Dlx genes, we examined transcriptional regulation of p107. Results: DLX2 occupies the p107 promoter in situ in the developing forebrain and retina and binds directly to sequences for the p107 promoter in vitro. In the absence of Dlx1/Dlx2, we observe reduced p107 expression. DLX2 binding to the p107 promoter results in significant activation of luciferase reporter gene expression in vitro. Conclusions: DLX2 binds to the p107 promoter in situ and in vitro, resulting in the activation of p107 expression in both the developing forebrain and retina. These findings contribute to our knowledge of genetic regulation of neurogenesis by Dlx homeobox genes and may contribute to identification of novel targets for disorders of neuronal differentiation and migration.
    URI
    http://hdl.handle.net/1993/5067
    Collections
    • FGS - Electronic Theses and Practica [25535]

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of MSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV