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dc.contributor.supervisor Suh, Miyoung (Human Nutritional Sciences) en_US
dc.contributor.author Peters, Leah
dc.date.accessioned 2011-08-30T18:59:54Z
dc.date.available 2011-08-30T18:59:54Z
dc.date.issued 2011-08-30
dc.identifier.uri http://hdl.handle.net/1993/4793
dc.description.abstract Fertility in human males is negatively correlated with obesity and diabetes mellitus (DM). Whether CLA influences obesity and DM associated infertility has not been studied. Seven-week-old male obese and DM-2 mice (db/db, n=40) were randomized to either an 8.5% (w/w) fat diet of a CLA isomer (0.4%, w/w) or a control diet for 6 weeks. Lean (n=10) mice were fed a control diet. The db/db mice fed a control diet displayed increased abnormal morphology, decreased sperm concentration. They also had decreased cst and cgt gene expression, despite increased seminolipid concentration, and decreased expression of genes involved in spermatogenesis compared to their lean counterparts. CLA isomers increased sperm number and normal sperm morphology, influenced seminolipid concentration, seminolipid enzyme gene expression and significantly increased Ccna1 gene expression. Seminolipid and genes of spermatogenesis appear to factor into DM and obesity induced reproductive dysfunction. Dietary CLA isomers appear to increase functionally viable sperm and thereby improve fertility. en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Conjugated Linoleic Acid en_US
dc.subject Spermatogenesis en_US
dc.title The effects of conjugated linoleic acid on spermatogenesis in DB/DB mice en_US
dc.type info:eu-repo/semantics/masterThesis
dc.degree.discipline Human Nutritional Sciences en_US
dc.contributor.examiningcommittee Taylor, Carla (Human Nutritional Sciences) Eskin, Michael (Human Nutritional Sciences) Huebner, Erwin (Biological Sciences) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2011 en_US


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