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dc.contributor.supervisorSuh, Miyoung (Human Nutritional Sciences)en_US
dc.contributor.authorPeters, Leah
dc.date.accessioned2011-08-30T18:59:54Z
dc.date.available2011-08-30T18:59:54Z
dc.date.issued2011-08-30
dc.identifier.urihttp://hdl.handle.net/1993/4793
dc.description.abstractFertility in human males is negatively correlated with obesity and diabetes mellitus (DM). Whether CLA influences obesity and DM associated infertility has not been studied. Seven-week-old male obese and DM-2 mice (db/db, n=40) were randomized to either an 8.5% (w/w) fat diet of a CLA isomer (0.4%, w/w) or a control diet for 6 weeks. Lean (n=10) mice were fed a control diet. The db/db mice fed a control diet displayed increased abnormal morphology, decreased sperm concentration. They also had decreased cst and cgt gene expression, despite increased seminolipid concentration, and decreased expression of genes involved in spermatogenesis compared to their lean counterparts. CLA isomers increased sperm number and normal sperm morphology, influenced seminolipid concentration, seminolipid enzyme gene expression and significantly increased Ccna1 gene expression. Seminolipid and genes of spermatogenesis appear to factor into DM and obesity induced reproductive dysfunction. Dietary CLA isomers appear to increase functionally viable sperm and thereby improve fertility.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectConjugated Linoleic Aciden_US
dc.subjectSpermatogenesisen_US
dc.titleThe effects of conjugated linoleic acid on spermatogenesis in DB/DB miceen_US
dc.typeinfo:eu-repo/semantics/masterThesis
dc.typemaster thesisen_US
dc.degree.disciplineHuman Nutritional Sciencesen_US
dc.contributor.examiningcommitteeTaylor, Carla (Human Nutritional Sciences) Eskin, Michael (Human Nutritional Sciences) Huebner, Erwin (Biological Sciences)en_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.noteOctober 2011en_US


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