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dc.contributor.supervisor Moffatt, Michael EK (Community Health Sciences) en
dc.contributor.author Schroth, Robert John
dc.date.accessioned 2010-10-13T17:10:17Z
dc.date.available 2010-10-13T17:10:17Z
dc.date.issued 2010-10-13T17:10:17Z
dc.identifier.uri http://hdl.handle.net/1993/4274
dc.description.abstract Objectives: Inadequate maternal vitamin D (25(OH)D) levels during pregnancy may affect primary tooth calcification predisposing enamel hypoplasia (EH), a risk factor for Early Childhood Caries (ECC). The purpose of the study was to determine the relationship between 25(OH)D status of expectant mothers and the incidence of EH and ECC among their infants. Methods: This prospective study recruited expectant mothers during their second trimester of pregnancy. A prenatal questionnaire was completed and serum sample drawn for a 25(OH)D assay. Infant dental exams, scheduled at approximately 12 months of age, determined EH and ECC, at which time the mother completed a second questionnaire. The dental examiner was blinded to each mother's prenatal vitamin D status. Results: 207 women, 90% of whom self-declared Aboriginal heritage, were enrolled at a mean age of 19.0 ± 4.7 years. The mean serum 25(OH)D was 48.1 ± 24.4 nmol/L. 35% had levels ≤ 35 nmol/L, a formerly-defined threshold of deficiency. Only 10% of women had concentrations ≥ 80 nmol/L, denoting adequacy. 135 infants were examined at 16.1 ± 7.4 months of age. EH was identified in 22% of infants, 23% had ECC and (36% ECC when white spot lesions were included). Mothers of children with EH had lower mean serum 25(OH)D concentrations during pregnancy than mothers of children without EH (43.2 ± 21.1 vs. 51.4 ± 27.4 nmol/L, p=.072). Mothers of children with ECC had lower 25(OH)D levels than mothers whose children were caries-free (41.4 ± 20.4 vs. 52.4 ± 27.4 nmol/L, p=.045). The rate of untreated decay was inversely related with maternal vitamin D concentrations (p<.001). Infants with EH were significantly more likely to have ECC (p<.001). Logistic regression identified low maternal calcium levels (p=.034), not having heard of vitamin D (p=.036), and not using margarine daily (p=.024) as being significantly associated with EH in the primary dentition of infants. Backwards logistic regression revealed that EH (p<.001), infant age (p=.002), and lower 25(OH)D levels during pregnancy (p=.019) were significantly associated with ECC. Conclusions: This study shows for the first time that maternal vitamin-D levels may influence primary dentition and the development of ECC in their babies. en
dc.format.extent 6225027 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject Vitamin D en
dc.subject Oral Health en
dc.subject Early Childhood Caries en
dc.subject Prospective Study en
dc.subject Prenatal en
dc.subject Infant en
dc.title Influence of Maternal Prenatal Vitamin D Status on Infant Oral Health en
dc.degree.discipline Community Health Sciences en
dc.contributor.examiningcommittee Lavelle, Christopher (Oral Biology) Tate, Robert (Community Health Sciences) Billings, Ronald (University of Rochester Medical Centre) en
dc.degree.level Doctor of Philosophy (Ph.D.) en
dc.description.note February 2011 en


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