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    Monofunctional platinum(ii) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks

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    Date
    2020-04-20
    Author
    Lozada, Issiah
    Huang, Bin
    Stilgenbauer, Morgan
    Beach, Travis
    Qiu, Zihan
    Zheng, Yaorong
    Herbert, David E
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    Abstract
    Phenanthriplatin is a leading preclinical anticancer Pt complex distinguished by a phenanthridine ligand that facilitates DNA-targeted covalent binding via intercalation. We report here that Pt(II) complexes incorporating phenanthridine into a chelating, multidentate ligand scaffold exhibit a superior in vitro therapeutic index compared with phenanthriplatin and cisplatin.
    URI
    http://hdl.handle.net/1993/36060
    DOI
    10.1039/D0DT01275K
    Collections
    • Faculty of Science Scholarly Works [209]
    • University of Manitoba Scholarship [1981]

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